Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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bioDDethiobiotin synthetase bioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (226 aa)    
Predicted Functional Partners:
BioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.999
bioB
Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
 
 0.999
BioF1
8-amino-7-oxononanoate synthase.
 
  
 0.995
RN09_1942
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase.
 
  
 0.978
RN09_1946
Hypothetical protein.
  
  
 0.963
BioF2
8-amino-7-oxononanoate synthase; Overlaps another CDS with the same product name.
 
  
 0.911
RN09_0045
8-amino-7-oxononanoate synthase; Overlaps another CDS with the same product name.
 
  
 0.885
BirA
Bifunctional biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase; Overlaps another CDS with the same product name.
  
  
 0.834
nadE
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
  
 0.832
RN09_1941
Membrane protein.
       0.719
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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