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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
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RN09_1964Imidazole glycerol phosphate synthase subunit HisH; Overlaps another CDS with the same product name. (90 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
 0.997
HisH
Imidazole glycerol phosphate synthase subunit HisH; Overlaps another CDS with the same product name.
     0.994
hisB
Imidazole glycerol-phosphate dehydratase.
 
  
 0.992
HisD
Histidinol dehydrogenase; Overlaps another CDS with the same product name; Belongs to the histidinol dehydrogenase family.
 
  
 0.987
hisC
Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.987
priA-2
Phosphoribosyl isomerase A; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family.
 
  
 0.987
HisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family.
 
  
 0.978
RN09_1959
Histidinol dehydrogenase; Overlaps another CDS with the same product name; Belongs to the histidinol dehydrogenase family.
 
  
 0.969
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
  
 0.961
ImpA
Inositol-monophosphatase ImpA.
  
  
 0.902
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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