trpE protein (Mycobacterium tuberculosis variant africanum)

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trpE

Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (516 aa)

Predicted Functional Partners:

TrpG

0.999

trpD

0.998

trpC

0.996

trpA

0.981

trpB

0.980

AroF

0.953

RN09_1157

0.919

RN09_2325

0.911

EntC

0.865

MbtI

0.862

Your Current Organism:

Mycobacterium tuberculosis variant africanum

NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AroF	EntC	RN09_3121	RN09_3908	Chorismate synthase; Overlaps another CDS with the same product name.	Isochorismate synthase.	0.903
AroF	MbtI	RN09_3121	RN09_2931	Chorismate synthase; Overlaps another CDS with the same product name.	Salicylate synthase.	0.917
AroF	RN09_1157	RN09_3121	RN09_1157	Chorismate synthase; Overlaps another CDS with the same product name.	Chorismate mutase.	0.952
AroF	RN09_2325	RN09_3121	RN09_2325	Chorismate synthase; Overlaps another CDS with the same product name.	Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate.	0.952
AroF	TrpG	RN09_3121	RN09_0021	Chorismate synthase; Overlaps another CDS with the same product name.	Anthranilate synthase component II.	0.910
AroF	trpA	RN09_3121	RN09_1977	Chorismate synthase; Overlaps another CDS with the same product name.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.739
AroF	trpB	RN09_3121	RN09_1976	Chorismate synthase; Overlaps another CDS with the same product name.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.704
AroF	trpC	RN09_3121	RN09_1975	Chorismate synthase; Overlaps another CDS with the same product name.	Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.	0.567
AroF	trpD	RN09_3121	RN09_2694	Chorismate synthase; Overlaps another CDS with the same product name.	Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).	0.693
AroF	trpE	RN09_3121	RN09_1973	Chorismate synthase; Overlaps another CDS with the same product name.	Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]	0.953
EntC	AroF	RN09_3908	RN09_3121	Isochorismate synthase.	Chorismate synthase; Overlaps another CDS with the same product name.	0.903
EntC	MbtI	RN09_3908	RN09_2931	Isochorismate synthase.	Salicylate synthase.	0.933
EntC	RN09_1157	RN09_3908	RN09_1157	Isochorismate synthase.	Chorismate mutase.	0.917
EntC	RN09_2325	RN09_3908	RN09_2325	Isochorismate synthase.	Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate.	0.917
EntC	TrpG	RN09_3908	RN09_0021	Isochorismate synthase.	Anthranilate synthase component II.	0.886
EntC	trpA	RN09_3908	RN09_1977	Isochorismate synthase.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.751
EntC	trpB	RN09_3908	RN09_1976	Isochorismate synthase.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.661
EntC	trpC	RN09_3908	RN09_1975	Isochorismate synthase.	Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.	0.768
EntC	trpD	RN09_3908	RN09_2694	Isochorismate synthase.	Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).	0.752
EntC	trpE	RN09_3908	RN09_1973	Isochorismate synthase.	Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]	0.865

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