Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
GabD2Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (518 aa)    
Predicted Functional Partners:
SucA
Putative 2-oxoglutarate dehydrogenase SUCA (alpha-ketoglutarate dehydrogenase); Multifunctional 2-oxoglutarate dehydrogenase E1 component /2-oxoglutarate dehydrogenase dihydrolipoyllysine-residue succinyltransferase.
  
 0.949
SdhA
Succinate dehydrogenase flavoprotein subunit; Overlaps another CDS with the same product name.
  
 0.945
GabT
4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.942
SdhB
Succinate dehydrogenase iron-sulfur protein subunit.
   
 
 0.940
FrdA
Fumarate reductase flavoprotein subunit; Overlaps another CDS with the same product name.
  
 0.939
SdhD
Succinate dehydrogenase hydrophobic membrane anchor subunit.
   
 
 0.938
GltA2
Citrate synthase 1; Belongs to the citrate synthase family.
  
 0.926
GabD1
Succinate-semialdehyde dehydrogenase.
  
  
 
0.921
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 0.920
RN09_0304
Succinate dehydrogenase flavoprotein subunit.
  
 0.918
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.