Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ureCUrease subunit alpha. (577 aa)    
Predicted Functional Partners:
ureA
Urease subunit gamma; Belongs to the urease gamma subunit family.
 0.999
ureB
Urease subunit beta; Belongs to the urease beta subunit family.
 0.999
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
 
  
 0.989
ureF
Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
 
 0.985
UreD
Urease accessory protein UreD.
  
 
 0.976
RN09_2850
Hypothetical protein.
     
  0.900
RN09_2279
Esterase.
       0.788
EsxB
ESAT-6-like protein EsxB.
      
 0.588
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
      
 0.558
GltB
Glutamate synthase large subunit.
      
 0.541
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.