Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LppKLipoprotein LppK. (189 aa)    
Predicted Functional Partners:
UvrD2
ATP-dependent DNA helicase UvrD.
  
 0.951
RN09_1996
DNA polymerase I; Overlaps another CDS with the same product name.
  
 0.943
PolA
DNA polymerase I; Overlaps another CDS with the same product name.
  
 0.943
RN09_1998
DNA polymerase I; Overlaps another CDS with the same product name.
  
 0.943
RN09_2603
Hypothetical protein.
       0.872
DnaA
Chromosomal replication initiator protein DnaA.
  
 
 0.850
XthA
Exodeoxyribonuclease III protein XthA.
   
 0.812
RN09_2964
Hypothetical protein.
   
 
 0.795
LprB
Lipoprotein LprB.
     
 0.793
arc
Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
  
 
 0.760
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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