Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (273 aa)    
Predicted Functional Partners:
HemY
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
 
 
 0.998
RN09_3263
Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family.
     0.991
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.980
HemD
uroporphyrin-III C-methyltransferase.
  
 
 0.947
CysG
Multifunctional uroporphyrin-III C-methyltransferase/precorrin-2 oxidase/ferrochelatase.
    
 0.947
RN09_0316
Transcriptional regulator.
  
 
 0.942
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.934
HemB
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.871
RN09_3261
Hypothetical protein.
  
  
 0.774
GltB
Glutamate synthase large subunit.
  
  
 0.764
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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