Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
HsdMType I restriction/modification system DNA methylase HsdM. (540 aa)    
Predicted Functional Partners:
HsdS
Type I restriction/modification system specificity determinant HsdS; Overlaps another CDS with the same product name.
 
 
 0.998
RN09_3353
Type I restriction/modification system specificity determinant HsdS; Overlaps another CDS with the same product name.
  
 
 0.986
vapC-31
Ribonuclease VapC21; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.
  
    0.807
Mrr
Restriction system protein.
 
  
 0.671
RocA
Pyrroline-5-carboxylate dehydrogenase RocA.
  
 
 0.650
SigI
ECF RNA polymerase sigma factor SigI.
      
 0.595
thyX
Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
   
   0.590
RN09_3350
Antitoxin VapB21.
       0.588
MutA
methylmalonyl-CoA mutase small subunit; Overlaps another CDS with the same product name.
      
 0.587
RN09_1540
Hypothetical protein.
  
  
 0.577
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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