Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EfpAMFS-type transporter EfpA. (530 aa)    
Predicted Functional Partners:
CysG
Multifunctional uroporphyrin-III C-methyltransferase/precorrin-2 oxidase/ferrochelatase.
       0.841
proS
proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...]
       0.819
CobO
cob(I)alamin adenosyltransferase.
       0.770
RN09_3453
Magnesium chelatase.
       0.754
RN09_3454
GCN5-like N-acetyltransferase.
       0.754
mqo
Malate:quinone oxidoreductase.
       0.707
AccD6
acetyl-/propionyl-CoA carboxylase subunit beta.
   
  
 0.623
CobB
Cobyrinic acid A,C-diamide synthase; Overlaps another CDS with the same product name.
       0.607
RN09_3451
Cobyrinic acid A,C-diamide synthase; Overlaps another CDS with the same product name.
       0.607
FadD32
long-chain-fatty-acid--AMP ligase FadD32.
   
  
 0.607
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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