RN09_3474 protein (Mycobacterium tuberculosis variant africanum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RN09_3474

GCN5-like N-acetyltransferase. (284 aa)

Predicted Functional Partners:

ispG

0.818

RN09_3476

0.795

dxr

0.795

RN09_2754

0.716

RN09_4438

0.694

arc

0.659

RN09_3665

0.654

RN09_3471

0.624

RN09_1833

0.602

RN09_3972

0.562

Your Current Organism:

Mycobacterium tuberculosis variant africanum

NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RN09_1833	RN09_3474	RN09_1833	RN09_3474	Hypothetical protein.	GCN5-like N-acetyltransferase.	0.602
RN09_1833	arc	RN09_1833	RN09_2601	Hypothetical protein.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.707
RN09_2754	RN09_3474	RN09_2754	RN09_3474	Hypothetical protein.	GCN5-like N-acetyltransferase.	0.716
RN09_2754	RN09_3665	RN09_2754	RN09_3665	Hypothetical protein.	Hypothetical protein.	0.617
RN09_2754	RN09_4438	RN09_2754	RN09_4438	Hypothetical protein.	Hypothetical protein.	0.594
RN09_2754	arc	RN09_2754	RN09_2601	Hypothetical protein.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.516
RN09_3471	RN09_3474	RN09_3471	RN09_3474	Penicillin-binding lipoprotein.	GCN5-like N-acetyltransferase.	0.624
RN09_3471	RN09_3476	RN09_3471	RN09_3476	Penicillin-binding lipoprotein.	Zinc metalloprotease.	0.581
RN09_3471	dxr	RN09_3471	RN09_3477	Penicillin-binding lipoprotein.	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.	0.542
RN09_3471	ispG	RN09_3471	RN09_3475	Penicillin-binding lipoprotein.	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.	0.559
RN09_3474	RN09_1833	RN09_3474	RN09_1833	GCN5-like N-acetyltransferase.	Hypothetical protein.	0.602
RN09_3474	RN09_2754	RN09_3474	RN09_2754	GCN5-like N-acetyltransferase.	Hypothetical protein.	0.716
RN09_3474	RN09_3471	RN09_3474	RN09_3471	GCN5-like N-acetyltransferase.	Penicillin-binding lipoprotein.	0.624
RN09_3474	RN09_3476	RN09_3474	RN09_3476	GCN5-like N-acetyltransferase.	Zinc metalloprotease.	0.795
RN09_3474	RN09_3665	RN09_3474	RN09_3665	GCN5-like N-acetyltransferase.	Hypothetical protein.	0.654
RN09_3474	RN09_3972	RN09_3474	RN09_3972	GCN5-like N-acetyltransferase.	Hypothetical protein.	0.562
RN09_3474	RN09_4438	RN09_3474	RN09_4438	GCN5-like N-acetyltransferase.	Hypothetical protein.	0.694
RN09_3474	arc	RN09_3474	RN09_2601	GCN5-like N-acetyltransferase.	Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.659
RN09_3474	dxr	RN09_3474	RN09_3477	GCN5-like N-acetyltransferase.	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.	0.795
RN09_3474	ispG	RN09_3474	RN09_3475	GCN5-like N-acetyltransferase.	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.	0.818