Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
moaA-2Cyclic pyranopterin monophosphate synthase 1; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (378 aa)    
Predicted Functional Partners:
moaC
Cyclic pyranopterin monophosphate synthase accessory protein 2; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
  
 0.997
moaC-3
Cyclic pyranopterin monophosphate synthase accessory protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
  
 0.993
moaC-2
Cyclic pyranopterin monophosphate synthase accessory protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
  
 0.986
moaA
Molybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
 
 
0.929
ribA
GTP cyclohydrolase-2; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family.
  
 
  0.904
MoaA1
Cyclic pyranopterin monophosphate synthase 1; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
  
  
 
0.901
folE
GTP cyclohydrolase I.
     
  0.900
RelA
Bifunctional (p)ppGpp synthase/hydrolase RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
    
  0.806
RN09_4459
Transmembrane protein.
   
 
  0.802
RN09_1257
Nucleoside triphosphate pyrophosphohydrolase.
     
  0.800
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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