GuaA protein (Mycobacterium tuberculosis variant africanum)

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Score

GuaA

GMP synthase. (205 aa)

Predicted Functional Partners:

GuaB2

0.998

GuaB1

0.994

GuaB3

0.994

gmk

0.983

Hpt

0.983

RN09_4174

0.982

RN09_4172

0.980

pyrG

0.974

RN09_1656

0.971

argS

0.970

Your Current Organism:

Mycobacterium tuberculosis variant africanum

NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GuaA	GuaB1	RN09_4153	RN09_2274	GMP synthase.	Inosine-5'-monophosphate dehydrogenase.	0.994
GuaA	GuaB2	RN09_4153	RN09_4173	GMP synthase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.998
GuaA	GuaB3	RN09_4153	RN09_4171	GMP synthase.	Oxidoreductase.	0.994
GuaA	Hpt	RN09_4153	RN09_4435	GMP synthase.	Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.983
GuaA	RN09_1656	RN09_4153	RN09_1656	GMP synthase.	Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.971
GuaA	RN09_4172	RN09_4153	RN09_4172	GMP synthase.	Inosine-5'-monophosphate dehydrogenase; Overlaps another CDS with the same product name.	0.980
GuaA	RN09_4174	RN09_4153	RN09_4174	GMP synthase.	Inosine-5'-monophosphate dehydrogenase; Overlaps another CDS with the same product name.	0.982
GuaA	argS	RN09_4153	RN09_1596	GMP synthase.	arginine--tRNA ligase.	0.970
GuaA	gmk	RN09_4153	RN09_1709	GMP synthase.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.983
GuaA	pyrG	RN09_4153	RN09_2087	GMP synthase.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.974
GuaB1	GuaA	RN09_2274	RN09_4153	Inosine-5'-monophosphate dehydrogenase.	GMP synthase.	0.994
GuaB1	GuaB2	RN09_2274	RN09_4173	Inosine-5'-monophosphate dehydrogenase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.924
GuaB1	GuaB3	RN09_2274	RN09_4171	Inosine-5'-monophosphate dehydrogenase.	Oxidoreductase.	0.972
GuaB1	Hpt	RN09_2274	RN09_4435	Inosine-5'-monophosphate dehydrogenase.	Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.914
GuaB1	RN09_1656	RN09_2274	RN09_1656	Inosine-5'-monophosphate dehydrogenase.	Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.919
GuaB1	RN09_4172	RN09_2274	RN09_4172	Inosine-5'-monophosphate dehydrogenase.	Inosine-5'-monophosphate dehydrogenase; Overlaps another CDS with the same product name.	0.781
GuaB1	RN09_4174	RN09_2274	RN09_4174	Inosine-5'-monophosphate dehydrogenase.	Inosine-5'-monophosphate dehydrogenase; Overlaps another CDS with the same product name.	0.780
GuaB1	gmk	RN09_2274	RN09_1709	Inosine-5'-monophosphate dehydrogenase.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.915
GuaB1	pyrG	RN09_2274	RN09_2087	Inosine-5'-monophosphate dehydrogenase.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.586
GuaB2	GuaA	RN09_4173	RN09_4153	Inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	GMP synthase.	0.998