Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PPE63PPE family protein PPE63; Belongs to the mycobacterial PPE family. (506 aa)    
Predicted Functional Partners:
PE36
PE family protein PE36.
      
 0.721
PE25
PE family protein PE25.
    
 
 0.661
RN09_4339
3-oxosteroid 1-dehydrogenase.
       0.629
RN09_4340
Dehydrogenase.
       0.629
PE5
PE family protein PE5.
    
 
 0.618
RN09_4338
Hydratase.
       0.460
RN09_4337
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
       0.457
RN09_4335
4-hydroxy-2-oxovalerate aldolase; Overlaps another CDS with the same product name.
       0.443
RN09_4336
4-hydroxy-2-oxovalerate aldolase; Overlaps another CDS with the same product name.
       0.443
PE15
PE family protein PE15.
    
 
 0.428
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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