Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RN09_4476Hypothetical protein. (287 aa)    
Predicted Functional Partners:
SerC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
 
  
 0.677
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.551
hisB
Imidazole glycerol-phosphate dehydratase.
  
  
 0.529
HisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family.
  
  
 0.529
priA-2
Phosphoribosyl isomerase A; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family.
  
  
 0.515
hisE
phosphoribosyl-ATP pyrophosphatase.
  
  
 0.503
HisH
Imidazole glycerol phosphate synthase subunit HisH; Overlaps another CDS with the same product name.
  
  
 0.500
RN09_1964
Imidazole glycerol phosphate synthase subunit HisH; Overlaps another CDS with the same product name.
  
  
 0.500
RN09_4477
Hypothetical protein.
      
 0.500
RN09_1959
Histidinol dehydrogenase; Overlaps another CDS with the same product name; Belongs to the histidinol dehydrogenase family.
  
  
 0.477
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.