Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RN09_4741ESX-1 secretion-associated protein EspK. (239 aa)    
Predicted Functional Partners:
RN09_4740
ESX-1 secretion-associated protein EspK.
  
   0.749
RN09_0865
Mycofactocin biosynthesis glycosyltransferase MftF.
  
 
 0.646
UvrD2
ATP-dependent DNA helicase UvrD.
   
 
 0.640
RN09_2817
Chaperone protein HtpG.
  
 0.631
RN09_2818
Chaperone protein HtpG.
  
 0.631
alaS
alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
   
 0.626
RN09_0386
Hypothetical protein.
  
 0.618
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.618
RN09_2781
Proline-rich protein.
  
 0.618
RN09_4219
Alanine/valine-rich protein.
  
 0.618
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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