STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuB3-isopropylmalate/3-methylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (365 aa)    
Predicted Functional Partners:
leuD
Isopropylmalate/citramalate isomerase, small subunit; Belongs to the LeuD family.
 
 
 0.999
leuC
Isopropylmalate/citramalate isomerase, large subunit; Belongs to the aconitase/IPM isomerase family.
 0.999
ilvN
Acetolactate synthase, small subunit.
 
 0.991
Pcar_1121
2-oxoacid decarboxylase/dehydrogenase/transferase, putative; Belongs to the TPP enzyme family.
 
 0.980
ilvB
Acetolactate synthase, large subunit, biosynthetic type.
 
 0.979
Pcar_0189
2-oxoacid decarboxylase/dehydrogenase/transferase, putative; Belongs to the TPP enzyme family.
 
 0.967
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
  
 0.962
tdcB
Threonine and serine dehydratase and deaminase, catabolic.
 
 
 0.956
ilvC
Ketol-acid reductoisomerase, class II; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.950
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.939
Your Current Organism:
Pelobacter carbinolicus
NCBI taxonomy Id: 338963
Other names: P. carbinolicus DSM 2380, Pelobacter carbinolicus DSM 2380, Pelobacter carbinolicus Gra Bd 1, Pelobacter carbinolicus str. DSM 2380, Pelobacter carbinolicus strain DSM 2380
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