Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ppro_1059
Hypothetical protein. (132 aa)
Predicted Functional Partners:
Ppro_1060
PFAM: type II secretion system protein E; General secretory system II, protein E domain protein; SMART: AAA ATPase; KEGG: ade:Adeh_1284 type II secretion system protein E.
0.714
Ppro_1058
Rubrerythrin; KEGG: gme:Gmet_1928 rubrerythrin.
0.432
Your Current Organism:
Pelobacter propionicus
NCBI taxonomy Id: 338966 Other names: P. propionicus DSM 2379, Pelobacter propionicus DSM 2379, Pelobacter propionicus str. DSM 2379, Pelobacter propionicus strain DSM 2379
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
node1
node2
node1 annotation
node2 annotation
score
Ppro_1058
Ppro_1059
Rubrerythrin; KEGG: gme:Gmet_1928 rubrerythrin.
Hypothetical protein.
0.432
Ppro_1059
Ppro_1058
Hypothetical protein.
Rubrerythrin; KEGG: gme:Gmet_1928 rubrerythrin.
0.432
Ppro_1059
Ppro_1060
Hypothetical protein.
PFAM: type II secretion system protein E; General secretory system II, protein E domain protein; SMART: AAA ATPase; KEGG: ade:Adeh_1284 type II secretion system protein E.
0.714
Ppro_1060
Ppro_1059
PFAM: type II secretion system protein E; General secretory system II, protein E domain protein; SMART: AAA ATPase; KEGG: ade:Adeh_1284 type II secretion system protein E.
Hypothetical protein.
0.714
Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) disable highlightexplain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: