node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ppro_1122 | der | Ppro_1122 | Ppro_1727 | PFAM: HMG-I and HMG-Y, DNA-binding domain protein; KEGG: nwi:Nwi_1258 hypothetical protein. | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.744 |
Ppro_2070 | cmk | Ppro_2070 | Ppro_1348 | PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: gsu:GSU1403 ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | KEGG: gme:Gmet_0865 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. | 0.948 |
Ppro_2070 | der | Ppro_2070 | Ppro_1727 | PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: gsu:GSU1403 ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.907 |
Ppro_2070 | era | Ppro_2070 | Ppro_1726 | PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: gsu:GSU1403 ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | 0.602 |
Ppro_2070 | ffh | Ppro_2070 | Ppro_1099 | PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: gsu:GSU1403 ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the i [...] | 0.514 |
Ppro_2070 | ftsY | Ppro_2070 | Ppro_3317 | PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: gsu:GSU1403 ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. | 0.558 |
Ppro_3506 | der | Ppro_3506 | Ppro_1727 | TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein; KEGG: gsu:GSU0500 GTP-binding protein TypA. | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.764 |
cmk | Ppro_2070 | Ppro_1348 | Ppro_2070 | KEGG: gme:Gmet_0865 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. | PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: gsu:GSU1403 ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.948 |
cmk | der | Ppro_1348 | Ppro_1727 | KEGG: gme:Gmet_0865 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.983 |
cmk | ffh | Ppro_1348 | Ppro_1099 | KEGG: gme:Gmet_0865 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. | Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the i [...] | 0.747 |
cmk | ftsY | Ppro_1348 | Ppro_3317 | KEGG: gme:Gmet_0865 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. | 0.542 |
cmk | gpsA | Ppro_1348 | Ppro_0007 | KEGG: gme:Gmet_0865 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: gsu:GSU0006 glycerol-3-phosphate dehydrogenase (NAD(P)+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.457 |
der | Ppro_1122 | Ppro_1727 | Ppro_1122 | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | PFAM: HMG-I and HMG-Y, DNA-binding domain protein; KEGG: nwi:Nwi_1258 hypothetical protein. | 0.744 |
der | Ppro_2070 | Ppro_1727 | Ppro_2070 | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: gsu:GSU1403 ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. | 0.907 |
der | Ppro_3506 | Ppro_1727 | Ppro_3506 | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein; KEGG: gsu:GSU0500 GTP-binding protein TypA. | 0.764 |
der | cmk | Ppro_1727 | Ppro_1348 | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | KEGG: gme:Gmet_0865 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. | 0.983 |
der | dnaG | Ppro_1727 | Ppro_3050 | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.744 |
der | era | Ppro_1727 | Ppro_1726 | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | 0.798 |
der | ffh | Ppro_1727 | Ppro_1099 | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the i [...] | 0.710 |
der | ftsY | Ppro_1727 | Ppro_3317 | Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. | 0.738 |