node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ppro_0025 | Ppro_0949 | Ppro_0025 | Ppro_0949 | KEGG: gme:Gmet_3009 hypothetical protein. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.598 |
Ppro_0025 | coaE | Ppro_0025 | Ppro_2356 | KEGG: gme:Gmet_3009 hypothetical protein. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.421 |
Ppro_0025 | mutM | Ppro_0025 | Ppro_3608 | KEGG: gme:Gmet_3009 hypothetical protein. | DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.629 |
Ppro_0025 | polA | Ppro_0025 | Ppro_2835 | KEGG: gme:Gmet_3009 hypothetical protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.634 |
Ppro_0663 | Ppro_0949 | Ppro_0663 | Ppro_0949 | PFAM: HhH-GPD family protein; KEGG: gme:Gmet_1973 HhH-GPD. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.598 |
Ppro_0663 | coaE | Ppro_0663 | Ppro_2356 | PFAM: HhH-GPD family protein; KEGG: gme:Gmet_1973 HhH-GPD. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.421 |
Ppro_0663 | mutM | Ppro_0663 | Ppro_3608 | PFAM: HhH-GPD family protein; KEGG: gme:Gmet_1973 HhH-GPD. | DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.721 |
Ppro_0663 | polA | Ppro_0663 | Ppro_2835 | PFAM: HhH-GPD family protein; KEGG: gme:Gmet_1973 HhH-GPD. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.634 |
Ppro_0949 | Ppro_0025 | Ppro_0949 | Ppro_0025 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | KEGG: gme:Gmet_3009 hypothetical protein. | 0.598 |
Ppro_0949 | Ppro_0663 | Ppro_0949 | Ppro_0663 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | PFAM: HhH-GPD family protein; KEGG: gme:Gmet_1973 HhH-GPD. | 0.598 |
Ppro_0949 | gyrB | Ppro_0949 | Ppro_0004 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.603 |
Ppro_0949 | mutM | Ppro_0949 | Ppro_3608 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.783 |
Ppro_0949 | polA | Ppro_0949 | Ppro_2835 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.907 |
Ppro_0949 | recA | Ppro_0949 | Ppro_3179 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.973 |
Ppro_0949 | ruvA | Ppro_0949 | Ppro_2671 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.578 |
Ppro_0949 | uvrC | Ppro_0949 | Ppro_3248 | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.511 |
Ppro_3609 | mutM | Ppro_3609 | Ppro_3608 | PFAM: protein of unknown function DUF559; KEGG: gsu:GSU1369 hypothetical protein. | DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.527 |
coaE | Ppro_0025 | Ppro_2356 | Ppro_0025 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | KEGG: gme:Gmet_3009 hypothetical protein. | 0.421 |
coaE | Ppro_0663 | Ppro_2356 | Ppro_0663 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | PFAM: HhH-GPD family protein; KEGG: gme:Gmet_1973 HhH-GPD. | 0.421 |
coaE | mutM | Ppro_2356 | Ppro_3608 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.939 |