| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rfer_1282 | hemA | Rfer_1282 | Rfer_1281 | Hypothetical protein. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.637 |
| Rfer_1282 | prfA | Rfer_1282 | Rfer_1280 | Hypothetical protein. | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.478 |
| Rfer_1716 | Rfer_2883 | Rfer_1716 | Rfer_2883 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.950 |
| Rfer_1716 | Rfer_3805 | Rfer_1716 | Rfer_3805 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.892 |
| Rfer_1716 | hemA | Rfer_1716 | Rfer_1281 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.679 |
| Rfer_1716 | hemC | Rfer_1716 | Rfer_1715 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
| Rfer_1716 | hemE | Rfer_1716 | Rfer_0821 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.947 |
| Rfer_1716 | hemL | Rfer_1716 | Rfer_1369 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.569 |
| Rfer_2883 | Rfer_1716 | Rfer_2883 | Rfer_1716 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.950 |
| Rfer_2883 | Rfer_3805 | Rfer_2883 | Rfer_3805 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.921 |
| Rfer_2883 | hemA | Rfer_2883 | Rfer_1281 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.859 |
| Rfer_2883 | hemC | Rfer_2883 | Rfer_1715 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.992 |
| Rfer_2883 | hemE | Rfer_2883 | Rfer_0821 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.937 |
| Rfer_2883 | hemL | Rfer_2883 | Rfer_1369 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.775 |
| Rfer_3805 | Rfer_1716 | Rfer_3805 | Rfer_1716 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.892 |
| Rfer_3805 | Rfer_2883 | Rfer_3805 | Rfer_2883 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.921 |
| Rfer_3805 | hemA | Rfer_3805 | Rfer_1281 | Porphobilinogen synthase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.891 |
| Rfer_3805 | hemC | Rfer_3805 | Rfer_1715 | Porphobilinogen synthase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
| Rfer_3805 | hemE | Rfer_3805 | Rfer_0821 | Porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.872 |
| Rfer_3805 | hemL | Rfer_3805 | Rfer_1369 | Porphobilinogen synthase; Belongs to the ALAD family. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.993 |