| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rfer_1977 | rnr | Rfer_1977 | Rfer_1976 | Short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.708 |
| Rfer_2003 | metG | Rfer_2003 | Rfer_3275 | tRNA/rRNA methyltransferase (SpoU). | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.704 |
| Rfer_2003 | rnr | Rfer_2003 | Rfer_1976 | tRNA/rRNA methyltransferase (SpoU). | RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.622 |
| Rfer_2003 | rsmA | Rfer_2003 | Rfer_0096 | tRNA/rRNA methyltransferase (SpoU). | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.447 |
| Rfer_2827 | rnr | Rfer_2827 | Rfer_1976 | 3'-5' exonuclease. | RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.831 |
| Rfer_2827 | rph | Rfer_2827 | Rfer_1629 | 3'-5' exonuclease. | RNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.939 |
| Rfer_2827 | rpsL | Rfer_2827 | Rfer_3800 | 3'-5' exonuclease. | SSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. | 0.763 |
| Rfer_2827 | rpsQ | Rfer_2827 | Rfer_3786 | 3'-5' exonuclease. | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. | 0.780 |
| Rfer_2827 | rsmA | Rfer_2827 | Rfer_0096 | 3'-5' exonuclease. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.861 |
| metG | Rfer_2003 | Rfer_3275 | Rfer_2003 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | tRNA/rRNA methyltransferase (SpoU). | 0.704 |
| metG | rlmB | Rfer_3275 | Rfer_2232 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | RNA methyltransferase TrmH, group 3; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. | 0.704 |
| metG | rnr | Rfer_3275 | Rfer_1976 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.629 |
| metG | rpsL | Rfer_3275 | Rfer_3800 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | SSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. | 0.490 |
| metG | rpsQ | Rfer_3275 | Rfer_3786 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. | 0.558 |
| metG | rpsR | Rfer_3275 | Rfer_2195 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | SSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. | 0.540 |
| metG | rsmA | Rfer_3275 | Rfer_0096 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.741 |
| rlmB | metG | Rfer_2232 | Rfer_3275 | RNA methyltransferase TrmH, group 3; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.704 |
| rlmB | rnr | Rfer_2232 | Rfer_1976 | RNA methyltransferase TrmH, group 3; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. | RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.631 |
| rlmB | rpsR | Rfer_2232 | Rfer_2195 | RNA methyltransferase TrmH, group 3; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. | SSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. | 0.468 |
| rlmB | rsmA | Rfer_2232 | Rfer_0096 | RNA methyltransferase TrmH, group 3; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.509 |
