| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rfer_0368 | Rfer_2071 | Rfer_0368 | Rfer_2071 | Ribonucleoside-triphosphate reductase, anaerobic. | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.904 |
| Rfer_0368 | Rfer_2284 | Rfer_0368 | Rfer_2284 | Ribonucleoside-triphosphate reductase, anaerobic. | Putative adenylate/guanylate cyclase. | 0.900 |
| Rfer_0368 | Rfer_3149 | Rfer_0368 | Rfer_3149 | Ribonucleoside-triphosphate reductase, anaerobic. | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.904 |
| Rfer_0368 | moaA | Rfer_0368 | Rfer_1468 | Ribonucleoside-triphosphate reductase, anaerobic. | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.815 |
| Rfer_0368 | ndk | Rfer_0368 | Rfer_2311 | Ribonucleoside-triphosphate reductase, anaerobic. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.908 |
| Rfer_0368 | ribB | Rfer_0368 | Rfer_2668 | Ribonucleoside-triphosphate reductase, anaerobic. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.806 |
| Rfer_2071 | Rfer_0368 | Rfer_2071 | Rfer_0368 | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Ribonucleoside-triphosphate reductase, anaerobic. | 0.904 |
| Rfer_2071 | Rfer_2284 | Rfer_2071 | Rfer_2284 | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Putative adenylate/guanylate cyclase. | 0.904 |
| Rfer_2071 | Rfer_3149 | Rfer_2071 | Rfer_3149 | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.922 |
| Rfer_2071 | moaA | Rfer_2071 | Rfer_1468 | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.807 |
| Rfer_2071 | ndk | Rfer_2071 | Rfer_2311 | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.916 |
| Rfer_2071 | ribB | Rfer_2071 | Rfer_2668 | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.846 |
| Rfer_2284 | Rfer_0368 | Rfer_2284 | Rfer_0368 | Putative adenylate/guanylate cyclase. | Ribonucleoside-triphosphate reductase, anaerobic. | 0.900 |
| Rfer_2284 | Rfer_2071 | Rfer_2284 | Rfer_2071 | Putative adenylate/guanylate cyclase. | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.904 |
| Rfer_2284 | Rfer_2321 | Rfer_2284 | Rfer_2321 | Putative adenylate/guanylate cyclase. | 2-oxoglutarate dehydrogenase E1 component. | 0.840 |
| Rfer_2284 | Rfer_3072 | Rfer_2284 | Rfer_3072 | Putative adenylate/guanylate cyclase. | Endonuclease. | 0.908 |
| Rfer_2284 | Rfer_3149 | Rfer_2284 | Rfer_3149 | Putative adenylate/guanylate cyclase. | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.904 |
| Rfer_2284 | Rfer_3942 | Rfer_2284 | Rfer_3942 | Putative adenylate/guanylate cyclase. | Serine/threonine protein kinase with Chase2 sensor. | 0.890 |
| Rfer_2284 | htpG | Rfer_2284 | Rfer_3551 | Putative adenylate/guanylate cyclase. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.873 |
| Rfer_2284 | moaA | Rfer_2284 | Rfer_1468 | Putative adenylate/guanylate cyclase. | GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.828 |