node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rfer_0654 | Rfer_1063 | Rfer_0654 | Rfer_1063 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase. | 0.921 |
Rfer_0654 | Rfer_3019 | Rfer_0654 | Rfer_3019 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein. | 0.943 |
Rfer_0654 | folD | Rfer_0654 | Rfer_2209 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.940 |
Rfer_0654 | glyA | Rfer_0654 | Rfer_2658 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.959 |
Rfer_0654 | thyA | Rfer_0654 | Rfer_2986 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.921 |
Rfer_0734 | Rfer_1063 | Rfer_0734 | Rfer_1063 | 5-nucleotidase. | Thymidylate synthase. | 0.900 |
Rfer_0734 | dut | Rfer_0734 | Rfer_2646 | 5-nucleotidase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
Rfer_0734 | surE | Rfer_0734 | Rfer_2782 | 5-nucleotidase. | 3'-nucleotidase / exopolyphosphatase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Rfer_0734 | thyA | Rfer_0734 | Rfer_2986 | 5-nucleotidase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
Rfer_0734 | tmk | Rfer_0734 | Rfer_2255 | 5-nucleotidase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.900 |
Rfer_1063 | Rfer_0654 | Rfer_1063 | Rfer_0654 | Thymidylate synthase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.921 |
Rfer_1063 | Rfer_0734 | Rfer_1063 | Rfer_0734 | Thymidylate synthase. | 5-nucleotidase. | 0.900 |
Rfer_1063 | Rfer_2985 | Rfer_1063 | Rfer_2985 | Thymidylate synthase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.993 |
Rfer_1063 | Rfer_3019 | Rfer_1063 | Rfer_3019 | Thymidylate synthase. | Glycine cleavage system T protein. | 0.921 |
Rfer_1063 | dut | Rfer_1063 | Rfer_2646 | Thymidylate synthase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.959 |
Rfer_1063 | folD | Rfer_1063 | Rfer_2209 | Thymidylate synthase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.935 |
Rfer_1063 | glyA | Rfer_1063 | Rfer_2658 | Thymidylate synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
Rfer_1063 | surE | Rfer_1063 | Rfer_2782 | Thymidylate synthase. | 3'-nucleotidase / exopolyphosphatase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.914 |
Rfer_1063 | thyA | Rfer_1063 | Rfer_2986 | Thymidylate synthase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.976 |
Rfer_1063 | tmk | Rfer_1063 | Rfer_2255 | Thymidylate synthase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.932 |