| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rfer_0002 | Rfer_3071 | Rfer_0002 | Rfer_3071 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Conserved hypothetical protein. | 0.847 |
| Rfer_0002 | Rfer_3074 | Rfer_0002 | Rfer_3074 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Hypothetical protein. | 0.559 |
| Rfer_0002 | Rfer_3477 | Rfer_0002 | Rfer_3477 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 5'-3' exonuclease. | 0.971 |
| Rfer_0002 | mutS | Rfer_0002 | Rfer_1832 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.978 |
| Rfer_0002 | polA | Rfer_0002 | Rfer_1325 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.988 |
| Rfer_3070 | Rfer_3071 | Rfer_3070 | Rfer_3071 | Sigma 28; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Conserved hypothetical protein. | 0.798 |
| Rfer_3070 | Rfer_3072 | Rfer_3070 | Rfer_3072 | Sigma 28; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Endonuclease. | 0.749 |
| Rfer_3070 | Rfer_3073 | Rfer_3070 | Rfer_3073 | Sigma 28; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Hypothetical protein. | 0.746 |
| Rfer_3070 | Rfer_3074 | Rfer_3070 | Rfer_3074 | Sigma 28; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Hypothetical protein. | 0.801 |
| Rfer_3070 | Rfer_3075 | Rfer_3070 | Rfer_3075 | Sigma 28; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | T/G mismatch-specific endonuclease; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. | 0.689 |
| Rfer_3070 | Rfer_3477 | Rfer_3070 | Rfer_3477 | Sigma 28; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 5'-3' exonuclease. | 0.626 |
| Rfer_3070 | polA | Rfer_3070 | Rfer_1325 | Sigma 28; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.540 |
| Rfer_3071 | Rfer_0002 | Rfer_3071 | Rfer_0002 | Conserved hypothetical protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.847 |
| Rfer_3071 | Rfer_3070 | Rfer_3071 | Rfer_3070 | Conserved hypothetical protein. | Sigma 28; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.798 |
| Rfer_3071 | Rfer_3072 | Rfer_3071 | Rfer_3072 | Conserved hypothetical protein. | Endonuclease. | 0.948 |
| Rfer_3071 | Rfer_3073 | Rfer_3071 | Rfer_3073 | Conserved hypothetical protein. | Hypothetical protein. | 0.945 |
| Rfer_3071 | Rfer_3074 | Rfer_3071 | Rfer_3074 | Conserved hypothetical protein. | Hypothetical protein. | 0.949 |
| Rfer_3071 | Rfer_3075 | Rfer_3071 | Rfer_3075 | Conserved hypothetical protein. | T/G mismatch-specific endonuclease; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. | 0.934 |
| Rfer_3071 | Rfer_3077 | Rfer_3071 | Rfer_3077 | Conserved hypothetical protein. | DNA-cytosine methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.802 |
| Rfer_3071 | Rfer_3477 | Rfer_3071 | Rfer_3477 | Conserved hypothetical protein. | 5'-3' exonuclease. | 0.802 |