Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
co-expression
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Rfer_4091Nickel-dependent hydrogenase, large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (568 aa)    
Predicted Functional Partners:
Rfer_4088
Hydrogenase (NiFe) small subunit (hydA).
 
 0.999
Rfer_4120
Uptake hydrogenase accessory protein HupU.
 
 0.997
Rfer_4092
HybD peptidase. Aspartic peptidase. MEROPS family A31.
 
 
 0.969
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.962
Rfer_4090
Polysulphide reductase, NrfD.
 
  
 0.936
Rfer_4094
Conserved hypothetical protein.
 
  
 0.935
Rfer_4099
Hydrogenase expression/formation protein HypD; Belongs to the HypD family.
 
 
 0.932
Rfer_4121
Hydrogen:quinone oxidoreductase.
 
  
 
0.927
Rfer_4097
(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
 
 
 0.912
Rfer_4096
Hydrogenase accessory protein HypB.
 
  
 0.911
Your Current Organism:
Rhodoferax ferrireducens
NCBI taxonomy Id: 338969
Other names: Albidiferax ferrireducens T118, R. ferrireducens T118, Rhodoferax ferrireducens ATCC BAA-621, Rhodoferax ferrireducens DSM 15236, Rhodoferax ferrireducens T118, Rhodoferax ferrireducens str. T118, Rhodoferax ferrireducens strain T118
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