STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PcaB3-carboxy-cis,cis-muconate cycloisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)    
Predicted Functional Partners:
PcaG
Protocatechuate 3,4-dioxygenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.998
PcaH
Protocatechuate 3,4-dioxygenase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.998
PcaL1
4-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.995
PcaL2
3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.983
pcaC
4-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.951
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.911
PcaJ
succinyl-CoA--3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.899
PcaI
succinyl-CoA--3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.889
purF
Amidophosphoribosyltransferase; Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.887
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family.
  
 
 0.886
Your Current Organism:
Streptomyces avermitilis
NCBI taxonomy Id: 33903
Other names: ATCC 31267, DSM 46492, JCM 5070, NBRC 14893, NCIMB 12804, NRRL 8165, S. avermitilis, Streptomyces avermectinius, Streptomyces avermectinius Takahashi et al. 2002, strain MA-4680
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