node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTHE_0987 | hisB | BTHE_0987 | BTHE_0766 | TrpE Anthranilate synthase component I. | Imidazoleglycerol-phosphate dehydratase. | 0.690 |
BTHE_0987 | hisE | BTHE_0987 | BTHE_0982 | TrpE Anthranilate synthase component I. | phosphoribosyl-ATP pyrophosphatase. | 0.626 |
BTHE_0987 | hisF | BTHE_0987 | BTHE_0989 | TrpE Anthranilate synthase component I. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.770 |
BTHE_0987 | hisG | BTHE_0987 | BTHE_0981 | TrpE Anthranilate synthase component I. | HisG ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.622 |
BTHE_0987 | hisI | BTHE_0987 | BTHE_0988 | TrpE Anthranilate synthase component I. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.892 |
BTHE_0987 | trpA | BTHE_0987 | BTHE_0985 | TrpE Anthranilate synthase component I. | TrpA Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.989 |
BTHE_0987 | trpC | BTHE_0987 | BTHE_0986 | TrpE Anthranilate synthase component I. | Indole-3-glycerol phosphate synthase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpC family. | 0.990 |
hisA | hisB | BTHE_0763 | BTHE_0766 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.996 |
hisA | hisD | BTHE_0763 | BTHE_0768 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.989 |
hisA | hisE | BTHE_0763 | BTHE_0982 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | phosphoribosyl-ATP pyrophosphatase. | 0.914 |
hisA | hisF | BTHE_0763 | BTHE_0989 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.996 |
hisA | hisG | BTHE_0763 | BTHE_0981 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | HisG ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.951 |
hisA | hisH | BTHE_0763 | BTHE_0764 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | BTHE_0763 | BTHE_0988 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.996 |
hisA | trpA | BTHE_0763 | BTHE_0985 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | TrpA Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.427 |
hisA | trpC | BTHE_0763 | BTHE_0986 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Indole-3-glycerol phosphate synthase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpC family. | 0.699 |
hisB | BTHE_0987 | BTHE_0766 | BTHE_0987 | Imidazoleglycerol-phosphate dehydratase. | TrpE Anthranilate synthase component I. | 0.690 |
hisB | hisA | BTHE_0766 | BTHE_0763 | Imidazoleglycerol-phosphate dehydratase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.996 |
hisB | hisD | BTHE_0766 | BTHE_0768 | Imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisB | hisE | BTHE_0766 | BTHE_0982 | Imidazoleglycerol-phosphate dehydratase. | phosphoribosyl-ATP pyrophosphatase. | 0.915 |