KZN94663.1 protein (Aeribacillus pallidus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

KZN94663.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)

Predicted Functional Partners:

KZN94662.1

0.590

KZN94664.1

0.458

KZN94665.1

0.458

KZN94666.1

0.458

Your Current Organism:

Aeribacillus pallidus

NCBI taxonomy Id: 33936
Other names: A. pallidus, ATCC 51176, Bacillus pallidus, DSM 3670, Geobacillus pallidus, Geobacillus sp. 8, Geobacillus sp. 8m3, LMG 19006, LMG:19006, strain H12

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KZN94662.1	KZN94663.1	AZI98_18335	AZI98_18340	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0346 family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.590
KZN94663.1	KZN94662.1	AZI98_18340	AZI98_18335	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0346 family.	0.590
KZN94663.1	KZN94664.1	AZI98_18340	AZI98_18345	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.458
KZN94663.1	KZN94665.1	AZI98_18340	AZI98_18350	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.458
KZN94663.1	KZN94666.1	AZI98_18340	AZI98_18355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sporulation protein SpoOM; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.458
KZN94664.1	KZN94663.1	AZI98_18345	AZI98_18340	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.458
KZN94664.1	KZN94665.1	AZI98_18345	AZI98_18350	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
KZN94664.1	KZN94666.1	AZI98_18345	AZI98_18355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Sporulation protein SpoOM; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
KZN94665.1	KZN94663.1	AZI98_18350	AZI98_18340	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.458
KZN94665.1	KZN94664.1	AZI98_18350	AZI98_18345	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
KZN94665.1	KZN94666.1	AZI98_18350	AZI98_18355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sporulation protein SpoOM; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.926
KZN94666.1	KZN94663.1	AZI98_18355	AZI98_18340	Sporulation protein SpoOM; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.458
KZN94666.1	KZN94664.1	AZI98_18355	AZI98_18345	Sporulation protein SpoOM; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
KZN94666.1	KZN94665.1	AZI98_18355	AZI98_18350	Sporulation protein SpoOM; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.926

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.761

expected number of edges:

12

PPI enrichment p-value:

9.59e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018105

Peptidyl-serine phosphorylation

3 of 90

1.9

1.1

0.0072

GO:0071218

Cellular response to misfolded protein

2 of 19

2.4

0.99

0.0155

GO:0051247

Positive regulation of protein metabolic process

3 of 135

1.73

0.96

0.0118

GO:0006515

Protein quality control for misfolded or incompletely synthesized proteins

2 of 43

2.05

0.73

0.0434

GO:0045862

Positive regulation of proteolysis

2 of 57

1.93

0.71

0.0450

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004842

Ubiquitin-protein transferase activity

4 of 422

1.36

0.82

0.0137

GO:0061630

Ubiquitin protein ligase activity

3 of 225

1.51

0.74

0.0291

GO:0140096

Catalytic activity, acting on a protein

9 of 3324

0.81

0.69

0.00053

GO:0016740

Transferase activity

10 of 4634

0.71

0.6

0.00053

GO:0016301

Kinase activity

6 of 1874

0.89

0.56

0.0178

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005776

Autophagosome

2 of 22

2.34

0.79

0.0353

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13820

Mixed, incl. Ubiquitin conjugating enzyme activity, and Ubiquitin homologues

3 of 84

1.93

0.83

0.0263

CL:20418

Mixed, incl. MAP kinase activity, and Rho (Ras homology) subfamily of Ras-like small GTPases

2 of 21

2.36

0.82

0.0312

CL:35943

Autophagy - other

2 of 23

2.32

0.82

0.0317

CL:13925

Ubiquitin conjugating enzyme activity, and Lipid desaturase domain

2 of 27

2.25

0.78

0.0375

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005776

Autophagosome

2 of 17

2.45

0.81

0.0341

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045202

CHIP , U-box domain

2 of 2

3.38

1.25

0.0056

IPR045200

E3 ubiquitin-protein ligase CHIP

2 of 2

3.38

1.25

0.0056

IPR000433

Zinc finger, ZZ-type

2 of 8

2.78

1.03

0.0139

IPR043145

Zinc finger, ZZ-type superfamily

2 of 9

2.73

1.02

0.0139

IPR027370

Zinc finger, RING-type, eukaryotic

2 of 12

2.6

0.98

0.0168

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00028

Tetratricopeptide repeats

3 of 67

2.03

1.47

0.0014

SM00291

Zinc-binding domain, present in Dystrophin, CREB-binding protein.

2 of 15

2.51

1.25

0.0052

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