node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OJG17644.1 | OJG18653.1 | RU95_GL002829 | RU95_GL002496 | Hypothetical protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.921 |
OJG17644.1 | fhs | RU95_GL002829 | RU95_GL002449 | Hypothetical protein. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.951 |
OJG17644.1 | folD | RU95_GL002829 | RU95_GL001681 | Hypothetical protein. | FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.482 |
OJG17644.1 | glyA | RU95_GL002829 | RU95_GL003644 | Hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
OJG17644.1 | guaA | RU95_GL002829 | RU95_GL001371 | Hypothetical protein. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.579 |
OJG17644.1 | purH | RU95_GL002829 | RU95_GL002332 | Hypothetical protein. | Bifunctional purine biosynthesis protein purH. | 0.922 |
OJG17644.1 | purN | RU95_GL002829 | RU95_GL002333 | Hypothetical protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.920 |
OJG18653.1 | OJG17644.1 | RU95_GL002496 | RU95_GL002829 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein. | 0.921 |
OJG18653.1 | OJG20652.1 | RU95_GL002496 | RU95_GL002169 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.922 |
OJG18653.1 | fhs | RU95_GL002496 | RU95_GL002449 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.926 |
OJG18653.1 | glyA | RU95_GL002496 | RU95_GL003644 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.929 |
OJG18653.1 | purH | RU95_GL002496 | RU95_GL002332 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional purine biosynthesis protein purH. | 0.919 |
OJG18653.1 | purN | RU95_GL002496 | RU95_GL002333 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.922 |
OJG19082.1 | fhs | RU95_GL002450 | RU95_GL002449 | Cold shock protein. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.829 |
OJG20652.1 | OJG18653.1 | RU95_GL002169 | RU95_GL002496 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.922 |
OJG20652.1 | fhs | RU95_GL002169 | RU95_GL002449 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.759 |
OJG20652.1 | folD | RU95_GL002169 | RU95_GL001681 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.540 |
OJG20652.1 | glyA | RU95_GL002169 | RU95_GL003644 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.736 |
OJG20652.1 | guaA | RU95_GL002169 | RU95_GL001371 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.676 |
OJG20652.1 | purH | RU95_GL002169 | RU95_GL002332 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Bifunctional purine biosynthesis protein purH. | 0.451 |