STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: msu:MS1891 histidinol-phosphate aminotransferase/Tyrosine aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (350 aa)    
Predicted Functional Partners:
hisB
TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase central region; KEGG: pmu:PM1200 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.995
hisI
PFAM: phosphoribosyl-AMP cyclohydrolase; MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: msu:MS1881 phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family.
 
  
 0.990
Asuc_1569
TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; KEGG: msu:MS1102 prephenate dehydrogenase.
 
 
 0.988
Asuc_1924
TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; KEGG: hin:HI1145 chorismate mutase (CM) / prephenate dehydratase (PDT) (P-protein).
 
 
 0.954
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.952
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.932
hisA
TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: msu:MS1883 phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase.
 
  
 0.923
Asuc_1574
Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: hit:NTHI1423 aspartate aminotransferase.
   
 
 0.911
hisC-2
TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: msu:MS1574 histidinol-phosphate aminotransferase/Tyrosine aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 
0.907
Your Current Organism:
Actinobacillus succinogenes
NCBI taxonomy Id: 339671
Other names: A. succinogenes 130Z, Actinobacillus succinogenes 130Z, Actinobacillus succinogenes str. 130Z, Actinobacillus succinogenes strain 130Z
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