STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
macBABC transporter related; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (643 aa)    
Predicted Functional Partners:
Asuc_1346
TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: msu:MS1128 membrane-fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.999
Asuc_0530
TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: msu:MS0454 AcrA protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.996
Asuc_1344
TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: msu:MS1131 TolC protein; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
 
 
 0.978
Asuc_1140
TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: msu:MS1304 TolC protein; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
 
 
 0.934
Asuc_1143
PFAM: secretion protein HlyD family protein; KEGG: msu:MS1301 membrane-fusion protein.
 
 
 0.919
Asuc_1667
PFAM: protein of unknown function DUF214; KEGG: pmu:PM0449 hypothetical Y. pestis.
 
 
 0.866
Asuc_1431
TIGRFAM: lipoprotein releasing system, transmembrane protein, LolC/E family; PFAM: protein of unknown function DUF214; KEGG: msu:MS1187 ABC-type transport systems, involved in lipoprotein release, permease components.
 
 
 0.854
Asuc_1429
TIGRFAM: lipoprotein releasing system, transmembrane protein, LolC/E family; lipoprotein releasing system, transmembrane protein LolE; PFAM: protein of unknown function DUF214; KEGG: msu:MS1185 ABC-type transport systems, involved in lipoprotein release, permease components.
  
 
 0.833
Asuc_1665
PFAM: YHS domain protein; KEGG: pmu:PM0451 hypothetical Y.pestis.
 
    0.792
lolA
Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
   
 
 0.707
Your Current Organism:
Actinobacillus succinogenes
NCBI taxonomy Id: 339671
Other names: A. succinogenes 130Z, Actinobacillus succinogenes 130Z, Actinobacillus succinogenes str. 130Z, Actinobacillus succinogenes strain 130Z
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