node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Asuc_0354 | Asuc_0355 | Asuc_0354 | Asuc_0355 | PFAM: protein of unknown function DUF513 hemX; KEGG: msu:MS0274 uncharacterized BCR. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.989 |
Asuc_0354 | cysG | Asuc_0354 | Asuc_1691 | PFAM: protein of unknown function DUF513 hemX; KEGG: msu:MS0274 uncharacterized BCR. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.911 |
Asuc_0354 | hemC | Asuc_0354 | Asuc_0356 | PFAM: protein of unknown function DUF513 hemX; KEGG: msu:MS0274 uncharacterized BCR. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.808 |
Asuc_0354 | hemE | Asuc_0354 | Asuc_1982 | PFAM: protein of unknown function DUF513 hemX; KEGG: msu:MS0274 uncharacterized BCR. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.904 |
Asuc_0355 | Asuc_0354 | Asuc_0355 | Asuc_0354 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: protein of unknown function DUF513 hemX; KEGG: msu:MS0274 uncharacterized BCR. | 0.989 |
Asuc_0355 | Asuc_0667 | Asuc_0355 | Asuc_0667 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: hso:HS_0548 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | 0.809 |
Asuc_0355 | cysG | Asuc_0355 | Asuc_1691 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.961 |
Asuc_0355 | hemC | Asuc_0355 | Asuc_0356 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
Asuc_0355 | hemE | Asuc_0355 | Asuc_1982 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.938 |
Asuc_0667 | Asuc_0355 | Asuc_0667 | Asuc_0355 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: hso:HS_0548 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.809 |
Asuc_0667 | cysG | Asuc_0667 | Asuc_1691 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: hso:HS_0548 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.871 |
Asuc_0667 | hemC | Asuc_0667 | Asuc_0356 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: hso:HS_0548 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
Asuc_0667 | hemE | Asuc_0667 | Asuc_1982 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: hso:HS_0548 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.737 |
Asuc_1687 | Asuc_1689 | Asuc_1687 | Asuc_1689 | Sulfite reductase (NADPH) flavoprotein, alpha chain; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: msu:MS1252 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. | 0.940 |
Asuc_1687 | Asuc_1690 | Asuc_1687 | Asuc_1690 | Sulfite reductase (NADPH) flavoprotein, alpha chain; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite. | 0.994 |
Asuc_1687 | cysG | Asuc_1687 | Asuc_1691 | Sulfite reductase (NADPH) flavoprotein, alpha chain; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.887 |
Asuc_1687 | cysI | Asuc_1687 | Asuc_1686 | Sulfite reductase (NADPH) flavoprotein, alpha chain; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.999 |
Asuc_1689 | Asuc_1687 | Asuc_1689 | Asuc_1687 | TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: msu:MS1252 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. | Sulfite reductase (NADPH) flavoprotein, alpha chain; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. | 0.940 |
Asuc_1689 | Asuc_1690 | Asuc_1689 | Asuc_1690 | TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: msu:MS1252 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. | Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite. | 0.989 |
Asuc_1689 | Asuc_1692 | Asuc_1689 | Asuc_1692 | TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: msu:MS1252 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. | TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; KEGG: msu:MS1255 ABC-type sulfate transport system, periplasmic component. | 0.991 |