node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Asuc_1268 | Asuc_1634 | Asuc_1268 | Asuc_1634 | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: msu:MS1368 superfamily I DNA and RNA helicases. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: cac:CAC1464 UvrA-like protein, probably involved in MDR transport. | 0.535 |
Asuc_1268 | mutL | Asuc_1268 | Asuc_0989 | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: msu:MS1368 superfamily I DNA and RNA helicases. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.588 |
Asuc_1268 | radA | Asuc_1268 | Asuc_1080 | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: msu:MS1368 superfamily I DNA and RNA helicases. | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.594 |
Asuc_1268 | recR | Asuc_1268 | Asuc_0998 | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: msu:MS1368 superfamily I DNA and RNA helicases. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.632 |
Asuc_1268 | rep | Asuc_1268 | Asuc_0682 | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: msu:MS1368 superfamily I DNA and RNA helicases. | ATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. | 0.916 |
Asuc_1268 | uvrA | Asuc_1268 | Asuc_1879 | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: msu:MS1368 superfamily I DNA and RNA helicases. | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.599 |
Asuc_1268 | uvrB | Asuc_1268 | Asuc_1089 | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: msu:MS1368 superfamily I DNA and RNA helicases. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.810 |
Asuc_1268 | uvrC | Asuc_1268 | Asuc_1724 | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: msu:MS1368 superfamily I DNA and RNA helicases. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.697 |
Asuc_1634 | Asuc_1268 | Asuc_1634 | Asuc_1268 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: cac:CAC1464 UvrA-like protein, probably involved in MDR transport. | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: msu:MS1368 superfamily I DNA and RNA helicases. | 0.535 |
Asuc_1634 | rep | Asuc_1634 | Asuc_0682 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: cac:CAC1464 UvrA-like protein, probably involved in MDR transport. | ATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. | 0.520 |
Asuc_1634 | uvrB | Asuc_1634 | Asuc_1089 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: cac:CAC1464 UvrA-like protein, probably involved in MDR transport. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.979 |
Asuc_1634 | uvrC | Asuc_1634 | Asuc_1724 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: cac:CAC1464 UvrA-like protein, probably involved in MDR transport. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.792 |
Asuc_1729 | radA | Asuc_1729 | Asuc_1080 | TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; PFAM: beta-lactamase domain protein; ComEC/Rec2-related protein; KEGG: hit:NTHI0073 recombination protein 2. | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.429 |
Asuc_1729 | uvrB | Asuc_1729 | Asuc_1089 | TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; PFAM: beta-lactamase domain protein; ComEC/Rec2-related protein; KEGG: hit:NTHI0073 recombination protein 2. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.452 |
Asuc_1729 | uvrC | Asuc_1729 | Asuc_1724 | TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; PFAM: beta-lactamase domain protein; ComEC/Rec2-related protein; KEGG: hit:NTHI0073 recombination protein 2. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.619 |
mutL | Asuc_1268 | Asuc_0989 | Asuc_1268 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: msu:MS1368 superfamily I DNA and RNA helicases. | 0.588 |
mutL | recR | Asuc_0989 | Asuc_0998 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.427 |
mutL | rep | Asuc_0989 | Asuc_0682 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | ATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. | 0.588 |
mutL | uvrA | Asuc_0989 | Asuc_1879 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.435 |
mutL | uvrB | Asuc_0989 | Asuc_1089 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.557 |