| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Asuc_0670 | Asuc_1987 | Asuc_0670 | Asuc_1987 | Pseudouridine synthase; PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: msu:MS0391 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | 0.468 |
| Asuc_0670 | truB | Asuc_0670 | Asuc_1123 | Pseudouridine synthase; PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: msu:MS0391 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.489 |
| Asuc_1987 | Asuc_0670 | Asuc_1987 | Asuc_0670 | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | Pseudouridine synthase; PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: msu:MS0391 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. | 0.468 |
| Asuc_1987 | Asuc_1988 | Asuc_1987 | Asuc_1988 | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | TIGRFAM: TRAP transporter solute receptor, TAXI family; KEGG: msu:MS0331 predicted periplasmic binding protein. | 0.554 |
| Asuc_1987 | mnmC | Asuc_1987 | Asuc_0887 | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | Protein of unknown function DUF752; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. | 0.524 |
| Asuc_1987 | mnmE | Asuc_1987 | Asuc_1976 | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.526 |
| Asuc_1987 | obg | Asuc_1987 | Asuc_0920 | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | GTP-binding protein Obg/CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.461 |
| Asuc_1987 | rapA | Asuc_1987 | Asuc_1992 | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | SNF2-related protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.463 |
| Asuc_1987 | rplQ | Asuc_1987 | Asuc_0485 | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | PFAM: ribosomal protein L17; KEGG: pmu:PM1389 50S ribosomal protein L17. | 0.425 |
| Asuc_1987 | rsfS | Asuc_1987 | Asuc_0695 | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.445 |
| Asuc_1987 | truB | Asuc_1987 | Asuc_1123 | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.508 |
| Asuc_1987 | truD | Asuc_1987 | Asuc_2053 | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | tRNA pseudouridine synthase D TruD; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. | 0.566 |
| Asuc_1988 | Asuc_1987 | Asuc_1988 | Asuc_1987 | TIGRFAM: TRAP transporter solute receptor, TAXI family; KEGG: msu:MS0331 predicted periplasmic binding protein. | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | 0.554 |
| mnmC | Asuc_1987 | Asuc_0887 | Asuc_1987 | Protein of unknown function DUF752; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | 0.524 |
| mnmC | mnmE | Asuc_0887 | Asuc_1976 | Protein of unknown function DUF752; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.618 |
| mnmE | Asuc_1987 | Asuc_1976 | Asuc_1987 | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific. | 0.526 |
| mnmE | mnmC | Asuc_1976 | Asuc_0887 | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | Protein of unknown function DUF752; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. | 0.618 |
| mnmE | obg | Asuc_1976 | Asuc_0920 | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | GTP-binding protein Obg/CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.510 |
| mnmE | rplQ | Asuc_1976 | Asuc_0485 | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | PFAM: ribosomal protein L17; KEGG: pmu:PM1389 50S ribosomal protein L17. | 0.657 |
| mnmE | rsfS | Asuc_1976 | Asuc_0695 | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.589 |
