HCAG_01383 protein (Histoplasma capsulatum NAm1)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

HCAG_01383

Uncharacterized protein; Belongs to the cytochrome b5 family. (337 aa)

Predicted Functional Partners:

HCAG_00765

0.684

HCAG_07200

0.684

HCAG_05596

0.632

HCAG_00357

0.627

HCAG_08974

0.599

HCAG_07971

0.555

HCAG_01226

0.549

HCAG_00764

0.536

HCAG_05084

0.501

HCAG_02777

0.498

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00357	HCAG_00765	A6QSK1	A6QTQ9	Mitochondrial import inner membrane translocase subunit tim22.	Nitrate reductase.	0.680
HCAG_00357	HCAG_01383	A6QSK1	A6QVH6	Mitochondrial import inner membrane translocase subunit tim22.	Uncharacterized protein; Belongs to the cytochrome b5 family.	0.627
HCAG_00357	HCAG_07200	A6QSK1	A6RC42	Mitochondrial import inner membrane translocase subunit tim22.	Uncharacterized protein.	0.647
HCAG_00357	HCAG_07971	A6QSK1	A6REA6	Mitochondrial import inner membrane translocase subunit tim22.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.647
HCAG_00764	HCAG_01383	A6QTQ8	A6QVH6	FMN hydroxy acid dehydrogenase domain-containing protein.	Uncharacterized protein; Belongs to the cytochrome b5 family.	0.536
HCAG_00765	HCAG_00357	A6QTQ9	A6QSK1	Nitrate reductase.	Mitochondrial import inner membrane translocase subunit tim22.	0.680
HCAG_00765	HCAG_01383	A6QTQ9	A6QVH6	Nitrate reductase.	Uncharacterized protein; Belongs to the cytochrome b5 family.	0.684
HCAG_00765	HCAG_02777	A6QTQ9	A6QZH0	Nitrate reductase.	Uncharacterized protein.	0.560
HCAG_00765	HCAG_05596	A6QTQ9	A6R7I8	Nitrate reductase.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.653
HCAG_00765	HCAG_07200	A6QTQ9	A6RC42	Nitrate reductase.	Uncharacterized protein.	0.912
HCAG_00765	HCAG_07971	A6QTQ9	A6REA6	Nitrate reductase.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.895
HCAG_01226	HCAG_01383	A6QV19	A6QVH6	FSH1 domain-containing protein.	Uncharacterized protein; Belongs to the cytochrome b5 family.	0.549
HCAG_01383	HCAG_00357	A6QVH6	A6QSK1	Uncharacterized protein; Belongs to the cytochrome b5 family.	Mitochondrial import inner membrane translocase subunit tim22.	0.627
HCAG_01383	HCAG_00764	A6QVH6	A6QTQ8	Uncharacterized protein; Belongs to the cytochrome b5 family.	FMN hydroxy acid dehydrogenase domain-containing protein.	0.536
HCAG_01383	HCAG_00765	A6QVH6	A6QTQ9	Uncharacterized protein; Belongs to the cytochrome b5 family.	Nitrate reductase.	0.684
HCAG_01383	HCAG_01226	A6QVH6	A6QV19	Uncharacterized protein; Belongs to the cytochrome b5 family.	FSH1 domain-containing protein.	0.549
HCAG_01383	HCAG_02777	A6QVH6	A6QZH0	Uncharacterized protein; Belongs to the cytochrome b5 family.	Uncharacterized protein.	0.498
HCAG_01383	HCAG_05084	A6QVH6	A6R626	Uncharacterized protein; Belongs to the cytochrome b5 family.	Malate synthase; Belongs to the malate synthase family.	0.501
HCAG_01383	HCAG_05596	A6QVH6	A6R7I8	Uncharacterized protein; Belongs to the cytochrome b5 family.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.632
HCAG_01383	HCAG_07200	A6QVH6	A6RC42	Uncharacterized protein; Belongs to the cytochrome b5 family.	Uncharacterized protein.	0.684

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Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.829

expected number of edges:

11

PPI enrichment p-value:

0.00667

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008654

Phospholipid biosynthetic process

8 of 37

1.88

4.02

3.63e-11

GO:0006650

Glycerophospholipid metabolic process

3 of 12

1.95

1.55

0.00079

GO:0044249

Cellular biosynthetic process

10 of 726

0.69

0.61

7.66e-05

GO:1901576

Organic substance biosynthetic process

10 of 756

0.67

0.59

9.28e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016780

Phosphotransferase activity, for other substituted phosphate groups

3 of 10

2.03

1.26

0.0037

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23500459

(2013) Bacterial lipids: metabolism and membrane homeostasis.

4 of 16

1.95

1.74

0.00030

PMID:32887610

(2020) Inducible intracellular membranes: molecular aspects and emerging applications.

3 of 7

2.18

1.45

0.0018

PMID:21255114

(2011) Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments.

2 of 2

2.55

0.87

0.0265

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1421

Glycerophospholipid metabolism

7 of 13

2.28

5.18

8.75e-12

CL:1373

Fatty acid biosynthesis, and Glycerophospholipid metabolism

8 of 37

1.88

4.15

1.23e-11

CL:1423

Glycerophospholipid metabolism

4 of 5

2.45

3.13

1.00e-06

CL:1437

Alditol phosphate metabolic process, and Phospholipid biosynthesis

2 of 5

2.15

0.84

0.0281

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsp00564

Glycerophospholipid metabolism

7 of 17

2.16

5.04

4.64e-12

rsp00561

Glycerolipid metabolism

2 of 11

1.81

0.93

0.0154

rsp01110

Biosynthesis of secondary metabolites

8 of 346

0.91

0.9

3.09e-05

rsp01100

Metabolic pathways

8 of 774

0.56

0.4

0.0087

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0594

Phospholipid biosynthesis

5 of 6

2.47

4.18

6.87e-09

KW-0444

Lipid biosynthesis

6 of 25

1.93

3.44

8.27e-09

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