HCAG_02131 protein (Histoplasma capsulatum NAm1)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

HCAG_02131

Uncharacterized protein. (268 aa)

Predicted Functional Partners:

HCAG_06536

0.978

HCAG_00740

0.960

HCAG_08342

0.960

HCAG_08343

0.960

HCAG_00486

0.953

HCAG_06802

0.951

HCAG_06160

0.869

HCAG_00020

0.868

HCAG_04531

0.836

HCAG_01815

0.834

Your Current Organism:

Histoplasma capsulatum NAm1

NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCAG_00020	HCAG_00740	A6QRL4	A6QTN4	Uncharacterized protein.	RRM domain-containing protein.	0.503
HCAG_00020	HCAG_01815	A6QRL4	A6QWQ8	Uncharacterized protein.	Mago nashi protein.	0.716
HCAG_00020	HCAG_02131	A6QRL4	A6QXM4	Uncharacterized protein.	Uncharacterized protein.	0.868
HCAG_00020	HCAG_04531	A6QRL4	A6R4H3	Uncharacterized protein.	RRM domain-containing protein.	0.851
HCAG_00020	HCAG_06536	A6QRL4	A6R895	Uncharacterized protein.	Pinin_SDK_memA domain-containing protein.	0.804
HCAG_00020	HCAG_08342	A6QRL4	A6RFC6	Uncharacterized protein.	Uncharacterized protein.	0.503
HCAG_00020	HCAG_08343	A6QRL4	A6RFC7	Uncharacterized protein.	Uncharacterized protein.	0.503
HCAG_00486	HCAG_02131	A6QSY0	A6QXM4	Chromatin assembly factor 1 subunit C.	Uncharacterized protein.	0.953
HCAG_00486	HCAG_06802	A6QSY0	A6R911	Chromatin assembly factor 1 subunit C.	Uncharacterized protein.	0.980
HCAG_00740	HCAG_00020	A6QTN4	A6QRL4	RRM domain-containing protein.	Uncharacterized protein.	0.503
HCAG_00740	HCAG_01815	A6QTN4	A6QWQ8	RRM domain-containing protein.	Mago nashi protein.	0.882
HCAG_00740	HCAG_02131	A6QTN4	A6QXM4	RRM domain-containing protein.	Uncharacterized protein.	0.960
HCAG_00740	HCAG_04531	A6QTN4	A6R4H3	RRM domain-containing protein.	RRM domain-containing protein.	0.854
HCAG_00740	HCAG_06160	A6QTN4	A6RB22	RRM domain-containing protein.	Uncharacterized protein.	0.569
HCAG_00740	HCAG_06536	A6QTN4	A6R895	RRM domain-containing protein.	Pinin_SDK_memA domain-containing protein.	0.574
HCAG_00740	HCAG_08342	A6QTN4	A6RFC6	RRM domain-containing protein.	Uncharacterized protein.	0.900
HCAG_00740	HCAG_08343	A6QTN4	A6RFC7	RRM domain-containing protein.	Uncharacterized protein.	0.900
HCAG_01815	HCAG_00020	A6QWQ8	A6QRL4	Mago nashi protein.	Uncharacterized protein.	0.716
HCAG_01815	HCAG_00740	A6QWQ8	A6QTN4	Mago nashi protein.	RRM domain-containing protein.	0.882
HCAG_01815	HCAG_02131	A6QWQ8	A6QXM4	Mago nashi protein.	Uncharacterized protein.	0.834

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.814

expected number of edges:

31

PPI enrichment p-value:

0.42

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009102

Biotin biosynthetic process

4 of 6

2.29

2.43

2.01e-05

GO:0072330

Monocarboxylic acid biosynthetic process

5 of 30

1.68

1.98

2.19e-05

GO:0046394

Carboxylic acid biosynthetic process

6 of 107

1.21

1.17

0.00022

GO:0044281

Small molecule metabolic process

7 of 429

0.67

0.46

0.0126

GO:0071704

Organic substance metabolic process

10 of 1181

0.39

0.28

0.0258

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36584052

(2022) The inside scoop: Comparative genomics of two intranuclear bacteria, Candidatus Berkiella cookevillensis and Candidatus Berkiella aquae.

4 of 114

1.01

0.78

0.0028

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1111

Biotin metabolic process

4 of 5

2.37

2.7

6.44e-06

CL:1034

Mixed, incl. Vitamin biosynthetic process, and Coenzyme A metabolic process

5 of 45

1.51

1.59

9.73e-05

CL:842

Small molecule biosynthetic process, and Nucleotide biosynthetic process

6 of 141

1.09

0.97

0.00055

CL:1311

Phosphopantetheine, and Fatty acid synthase activity

2 of 5

2.06

0.85

0.0254

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00780

Biotin metabolism

5 of 26

1.75

2.32

3.19e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0093

Biotin biosynthesis

2 of 3

2.29

0.9

0.0221

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