STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAC1Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs. (457 aa)    
Predicted Functional Partners:
HCAG_02657
Dynein heavy chain.
    
 0.946
HCAG_02658
Dynein heavy chain.
    
 0.946
HCAG_07329
NUDE_C domain-containing protein.
    
 
 0.946
HCAG_03912
Lysophospholipase.
     
 0.921
HCAG_04378
Putative phospholipase.
     
 0.920
HCAG_06231
Nuclear movement protein nudC.
   
 0.915
HCAG_02728
Uncharacterized protein.
   
 0.912
HCAG_06225
Patatin-like phospholipase domain-containing protein; Lipid hydrolase; Belongs to the PLPL family.
     
  0.900
HCAG_08267
Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.
     
  0.900
HCAG_05994
Dynactin domain-containing protein.
    
 0.859
Your Current Organism:
Histoplasma capsulatum NAm1
NCBI taxonomy Id: 339724
Other names: Ajellomyces capsulatus NAm1, H. capsulatum NAm1
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