node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Msp_0005 | Msp_0036 | Msp_0005 | Msp_0036 | Predicted helicase; COG1061, smart00487, cd00269. | Putative ATP-dependent helicase. | 0.958 |
Msp_0005 | fen | Msp_0005 | Msp_1086 | Predicted helicase; COG1061, smart00487, cd00269. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.941 |
Msp_0005 | rpoB1 | Msp_0005 | Msp_1374 | Predicted helicase; COG1061, smart00487, cd00269. | RpoB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.918 |
Msp_0005 | rpoD | Msp_0005 | Msp_0868 | Predicted helicase; COG1061, smart00487, cd00269. | RpoD; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.946 |
Msp_0005 | rpoH | Msp_0005 | Msp_1376 | Predicted helicase; COG1061, smart00487, cd00269. | RpoH; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.949 |
Msp_0005 | rpoK | Msp_0005 | Msp_0863 | Predicted helicase; COG1061, smart00487, cd00269. | RpoK; DNA-directed RNA polymerase subunit K. | 0.946 |
Msp_0005 | rpoN | Msp_0005 | Msp_0864 | Predicted helicase; COG1061, smart00487, cd00269. | RpoN; DNA-directed RNA polymerase subunit N. | 0.944 |
Msp_0005 | tbp | Msp_0005 | Msp_1097 | Predicted helicase; COG1061, smart00487, cd00269. | TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. | 0.953 |
Msp_0005 | tfb | Msp_0005 | Msp_1360 | Predicted helicase; COG1061, smart00487, cd00269. | Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). | 0.954 |
Msp_0005 | tfe | Msp_0005 | Msp_1272 | Predicted helicase; COG1061, smart00487, cd00269. | Predicted transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and dest [...] | 0.957 |
Msp_0036 | Msp_0005 | Msp_0036 | Msp_0005 | Putative ATP-dependent helicase. | Predicted helicase; COG1061, smart00487, cd00269. | 0.958 |
Msp_0036 | fen | Msp_0036 | Msp_1086 | Putative ATP-dependent helicase. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.961 |
Msp_0036 | rpoB1 | Msp_0036 | Msp_1374 | Putative ATP-dependent helicase. | RpoB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.949 |
Msp_0036 | rpoD | Msp_0036 | Msp_0868 | Putative ATP-dependent helicase. | RpoD; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.983 |
Msp_0036 | rpoH | Msp_0036 | Msp_1376 | Putative ATP-dependent helicase. | RpoH; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.978 |
Msp_0036 | rpoK | Msp_0036 | Msp_0863 | Putative ATP-dependent helicase. | RpoK; DNA-directed RNA polymerase subunit K. | 0.975 |
Msp_0036 | rpoN | Msp_0036 | Msp_0864 | Putative ATP-dependent helicase. | RpoN; DNA-directed RNA polymerase subunit N. | 0.975 |
Msp_0036 | tbp | Msp_0036 | Msp_1097 | Putative ATP-dependent helicase. | TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. | 0.975 |
Msp_0036 | tfb | Msp_0036 | Msp_1360 | Putative ATP-dependent helicase. | Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). | 0.977 |
Msp_0036 | tfe | Msp_0036 | Msp_1272 | Putative ATP-dependent helicase. | Predicted transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and dest [...] | 0.981 |