node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Msp_0252 | Msp_1258 | Msp_0252 | Msp_1258 | Predicted ribokinase; COG0524, pfam00294, cd01942; Belongs to the carbohydrate kinase PfkB family. | Predicted ribokinase; COG0524, cd01937. | 0.908 |
Msp_0252 | guaB | Msp_0252 | Msp_0431 | Predicted ribokinase; COG0524, pfam00294, cd01942; Belongs to the carbohydrate kinase PfkB family. | GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.921 |
Msp_0252 | purA | Msp_0252 | Msp_0986 | Predicted ribokinase; COG0524, pfam00294, cd01942; Belongs to the carbohydrate kinase PfkB family. | PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.963 |
Msp_0252 | purB | Msp_0252 | Msp_1247 | Predicted ribokinase; COG0524, pfam00294, cd01942; Belongs to the carbohydrate kinase PfkB family. | PurB; Adenylosuccinate lyase; COG0015, pfam00206; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.429 |
Msp_0490 | argG | Msp_0490 | Msp_1459 | Putative asparagine synthetase; COG0367, pfam00733, cd01991. | ArgG; Argininosuccinate synthase; COG0137, pfam00764, cd01999; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.931 |
Msp_0490 | purA | Msp_0490 | Msp_0986 | Putative asparagine synthetase; COG0367, pfam00733, cd01991. | PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.946 |
Msp_0490 | purL | Msp_0490 | Msp_1467 | Putative asparagine synthetase; COG0367, pfam00733, cd01991. | PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule f [...] | 0.485 |
Msp_0490 | pyrB | Msp_0490 | Msp_0003 | Putative asparagine synthetase; COG0367, pfam00733, cd01991. | PyrB; Aspartate carbamoyltransferase. | 0.949 |
Msp_1258 | Msp_0252 | Msp_1258 | Msp_0252 | Predicted ribokinase; COG0524, cd01937. | Predicted ribokinase; COG0524, pfam00294, cd01942; Belongs to the carbohydrate kinase PfkB family. | 0.908 |
Msp_1258 | guaB | Msp_1258 | Msp_0431 | Predicted ribokinase; COG0524, cd01937. | GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.921 |
Msp_1258 | purA | Msp_1258 | Msp_0986 | Predicted ribokinase; COG0524, cd01937. | PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.963 |
Msp_1258 | purB | Msp_1258 | Msp_1247 | Predicted ribokinase; COG0524, cd01937. | PurB; Adenylosuccinate lyase; COG0015, pfam00206; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.429 |
argG | Msp_0490 | Msp_1459 | Msp_0490 | ArgG; Argininosuccinate synthase; COG0137, pfam00764, cd01999; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Putative asparagine synthetase; COG0367, pfam00733, cd01991. | 0.931 |
argG | purA | Msp_1459 | Msp_0986 | ArgG; Argininosuccinate synthase; COG0137, pfam00764, cd01999; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.946 |
argG | purL | Msp_1459 | Msp_1467 | ArgG; Argininosuccinate synthase; COG0137, pfam00764, cd01999; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule f [...] | 0.400 |
argG | pyrB | Msp_1459 | Msp_0003 | ArgG; Argininosuccinate synthase; COG0137, pfam00764, cd01999; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | PyrB; Aspartate carbamoyltransferase. | 0.921 |
guaB | Msp_0252 | Msp_0431 | Msp_0252 | GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Predicted ribokinase; COG0524, pfam00294, cd01942; Belongs to the carbohydrate kinase PfkB family. | 0.921 |
guaB | Msp_1258 | Msp_0431 | Msp_1258 | GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Predicted ribokinase; COG0524, cd01937. | 0.921 |
guaB | purA | Msp_0431 | Msp_0986 | GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.990 |
guaB | purB | Msp_0431 | Msp_1247 | GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | PurB; Adenylosuccinate lyase; COG0015, pfam00206; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.858 |