STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tbpTATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (183 aa)    
Predicted Functional Partners:
tfb
Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
 
 0.999
tfe
Predicted transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and dest [...]
  
 0.993
rpoH
RpoH; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
  
 
 0.991
rpoD
RpoD; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 0.986
rpoN
RpoN; DNA-directed RNA polymerase subunit N.
  
 
 0.983
rpoE1
RpoE1; DNA-directed RNA polymerase subunit E'.
  
 
 0.981
rpoA2
RpoA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.981
rpoK
RpoK; DNA-directed RNA polymerase subunit K.
    
 0.978
rpl40e
50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
    
 0.977
rpoB2
RpoB2; DNA-directed RNA polymerase, subunit B''; COG0085, pfam04563, pfam04565, pfam045661; Belongs to the RNA polymerase beta chain family.
  
 
 0.976
Your Current Organism:
Methanosphaera stadtmanae
NCBI taxonomy Id: 339860
Other names: M. stadtmanae DSM 3091, Methanosphaera stadtmanae ATCC 43021, Methanosphaera stadtmanae DSM 3091, Methanosphaera stadtmanae MCB-3, Methanosphaera stadtmanae str. DSM 3091, Methanosphaera stadtmanae strain DSM 3091
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