Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABY93766.1PFAM: phage integrase family protein; Belongs to the 'phage' integrase family. (403 aa)    
Predicted Functional Partners:
ABY95425.1
PFAM: phosphoribosyltransferase.
   
    0.504
ABY93765.1
Hypothetical protein.
       0.489
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.463
ABY94640.1
PFAM: Prephenate dehydrogenase; TrkA-N domain protein; 6-phosphogluconate dehydrogenase, NAD-binding.
  
    0.446
whiA
Protein of unknown function DUF199; Involved in cell division and chromosome segregation.
   
    0.432
ABY93832.1
Purine operon repressor, PurR; TIGRFAM: pur operon repressor; PFAM: phosphoribosyltransferase; Pur operon repressor.
   
    0.418
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
    0.418
Your Current Organism:
Thermoanaerobacter pseudethanolicus
NCBI taxonomy Id: 340099
Other names: Clostridium thermohydrosulfuricum 39E, T. pseudethanolicus ATCC 33223, Thermoanaerobacter ethanolicus ATCC 33223, Thermoanaerobacter pseudethanolicus 39E, Thermoanaerobacter pseudethanolicus ATCC 33223, Thermoanaerobacter pseudethanolicus str. ATCC 33223, Thermoanaerobacter pseudethanolicus strain ATCC 33223
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