Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pars_0239PFAM: Rhomboid family protein; KEGG: pai:PAE1124 integral membrane protein (rhomboid related), putative. (251 aa)    
Predicted Functional Partners:
Pars_0238
PFAM: PaREP1 domain containing protein; KEGG: pai:PAE0843 paREP1.
       0.773
Pars_0840
PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: pis:Pisl_1420 5-formyltetrahydrofolate cyclo-ligase.
  
  
 0.644
tatA
Sec-independent protein translocase TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
  
 
 0.643
Pars_0015
PFAM: band 7 protein; KEGG: pis:Pisl_1055 band 7 protein.
  
 0.550
Pars_0842
PFAM: band 7 protein; KEGG: tpe:Tpen_0832 band 7 protein.
  
 0.550
Pars_2198
PFAM: band 7 protein; KEGG: pai:PAE0262 prohibitin homolog (HflK family).
  
 0.550
Pars_0241
PFAM: aldo/keto reductase; KEGG: pai:PAE1127 hypothetical protein.
    
  0.547
Pars_0240
KEGG: pai:PAE1126 hypothetical protein.
       0.516
Pars_2238
PFAM: peptidase M50; KEGG: pai:PAE1702 hypothetical protein.
  
  
 0.438
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
  
 0.433
Your Current Organism:
Pyrobaculum arsenaticum
NCBI taxonomy Id: 340102
Other names: P. arsenaticum DSM 13514, Pyrobaculum arsenaticum DSM 13514, Pyrobaculum arsenaticum str. DSM 13514, Pyrobaculum arsenaticum strain DSM 13514
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