STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobB-2PFAM: Silent information regulator protein Sir2; KEGG: pai:PAE3500 NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily. (269 aa)    
Predicted Functional Partners:
Pars_0405
KEGG: pis:Pisl_1561 nicotinamide-nucleotide adenylyltransferase; TIGRFAM: cytidyltransferase-related domain; nicotinamide-nucleotide adenylyltransferase; PFAM: cytidylyltransferase.
   
 
  0.956
Pars_1824
Cytidyltransferase-related domain protein; KEGG: pai:PAE2259 nicotinamide-nucleotide adenylyltransferase; TIGRFAM: cytidyltransferase-related domain; PFAM: cytidylyltransferase.
   
 
  0.956
Pars_2286
PFAM: ATP-NAD/AcoX kinase; KEGG: pai:PAE0624 NAD+ kinase.
  
 
 0.924
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.922
nadE-2
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.922
cobB
Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.
  
  
 
0.905
Pars_1871
Glutamate dehydrogenase (NAD); PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: pis:Pisl_0980 Glu/Leu/Phe/Val dehydrogenase, C terminal; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.664
Pars_2065
Glutamate dehydrogenase (NADP); PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: pai:PAE1996 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.664
Pars_1958
KEGG: pai:PAE3499 hypothetical protein.
       0.661
Pars_0110
KEGG: pai:PAE0891 hypothetical protein.
   
 
 0.605
Your Current Organism:
Pyrobaculum arsenaticum
NCBI taxonomy Id: 340102
Other names: P. arsenaticum DSM 13514, Pyrobaculum arsenaticum DSM 13514, Pyrobaculum arsenaticum str. DSM 13514, Pyrobaculum arsenaticum strain DSM 13514
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.