Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Pars_2289PFAM: Protein of unknown function DUF371; KEGG: pai:PAE0628 hypothetical protein. (156 aa)    
Predicted Functional Partners:
Pars_2288
KEGG: pai:PAE0627 hypothetical protein.
       0.907
tyrS
tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
       0.608
Pars_0772
PFAM: ERCC4 domain protein; KEGG: pai:PAE1735 hypothetical protein.
 
     0.558
gch3
GTP cyclohydrolase IIa; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
  
     0.557
Pars_2351
KEGG: pai:PAE0705 hypothetical protein.
  
     0.556
nusA
NusA family KH domain protein; Participates in transcription termination. Belongs to the NusA family.
  
     0.486
Pars_1934
KEGG: pai:PAE2210 hypothetical protein.
  
     0.475
hjc
Holliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family.
  
     0.467
Pars_1385
ATPase, PilT family; PFAM: type II secretion system protein E; KEGG: pai:PAE3216 hypothetical protein.
  
     0.461
Pars_1810
PFAM: regulatory protein, ArsR; transcriptional regulator TrmB; KEGG: pai:PAE2282 hypothetical protein.
  
     0.449
Your Current Organism:
Pyrobaculum arsenaticum
NCBI taxonomy Id: 340102
Other names: P. arsenaticum DSM 13514, Pyrobaculum arsenaticum DSM 13514, Pyrobaculum arsenaticum str. DSM 13514, Pyrobaculum arsenaticum strain DSM 13514
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