SIR07333.1 protein (Aromatoleum tolulyticum)

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Known Interactions

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Predicted Interactions

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Score

SIR07333.1

Predicted PurR-regulated permease PerM. (407 aa)

Predicted Functional Partners:

SIR07236.1

0.620

purE

0.484

SIQ70996.1

0.473

SIR07366.1

0.471

SIR07419.1

0.469

adk

0.451

SIR60758.1

0.442

SIR06774.1

0.424

SIR07452.1

0.417

Your Current Organism:

Aromatoleum tolulyticum

NCBI taxonomy Id: 34027
Other names: A. tolulyticum, ATCC 51758, Azoarcus denitrificans, Azoarcus tolulyticus, CIP 109470, strain Tol-4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SIQ70996.1	SIR07333.1	SAMN05421829_10697	SAMN05421829_109163	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Predicted PurR-regulated permease PerM.	0.473
SIQ70996.1	adk	SAMN05421829_10697	SAMN05421829_103281	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	0.962
SIQ70996.1	purE	SAMN05421829_10697	SAMN05421829_12356	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.977
SIR06774.1	SIR07333.1	SAMN05421829_109147	SAMN05421829_109163	AsmA protein/hypothetical protein.	Predicted PurR-regulated permease PerM.	0.424
SIR06774.1	SIR07452.1	SAMN05421829_109147	SAMN05421829_109167	AsmA protein/hypothetical protein.	Protein of unknown function.	0.495
SIR07236.1	SIR07333.1	SAMN05421829_109162	SAMN05421829_109163	Cellobiose phosphorylase.	Predicted PurR-regulated permease PerM.	0.620
SIR07236.1	SIR07366.1	SAMN05421829_109162	SAMN05421829_109164	Cellobiose phosphorylase.	Hyperosmotically inducible protein.	0.667
SIR07236.1	SIR07419.1	SAMN05421829_109162	SAMN05421829_109166	Cellobiose phosphorylase.	Protein of unknown function.	0.432
SIR07333.1	SIQ70996.1	SAMN05421829_109163	SAMN05421829_10697	Predicted PurR-regulated permease PerM.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.473
SIR07333.1	SIR06774.1	SAMN05421829_109163	SAMN05421829_109147	Predicted PurR-regulated permease PerM.	AsmA protein/hypothetical protein.	0.424
SIR07333.1	SIR07236.1	SAMN05421829_109163	SAMN05421829_109162	Predicted PurR-regulated permease PerM.	Cellobiose phosphorylase.	0.620
SIR07333.1	SIR07366.1	SAMN05421829_109163	SAMN05421829_109164	Predicted PurR-regulated permease PerM.	Hyperosmotically inducible protein.	0.471
SIR07333.1	SIR07419.1	SAMN05421829_109163	SAMN05421829_109166	Predicted PurR-regulated permease PerM.	Protein of unknown function.	0.469
SIR07333.1	SIR07452.1	SAMN05421829_109163	SAMN05421829_109167	Predicted PurR-regulated permease PerM.	Protein of unknown function.	0.417
SIR07333.1	SIR60758.1	SAMN05421829_109163	SAMN05421829_12312	Predicted PurR-regulated permease PerM.	Flagellar basal-body rod protein FlgG; Belongs to the flagella basal body rod proteins family.	0.442
SIR07333.1	adk	SAMN05421829_109163	SAMN05421829_103281	Predicted PurR-regulated permease PerM.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	0.451
SIR07333.1	purE	SAMN05421829_109163	SAMN05421829_12356	Predicted PurR-regulated permease PerM.	5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.484
SIR07366.1	SIR07236.1	SAMN05421829_109164	SAMN05421829_109162	Hyperosmotically inducible protein.	Cellobiose phosphorylase.	0.667
SIR07366.1	SIR07333.1	SAMN05421829_109164	SAMN05421829_109163	Hyperosmotically inducible protein.	Predicted PurR-regulated permease PerM.	0.471
SIR07366.1	SIR07419.1	SAMN05421829_109164	SAMN05421829_109166	Hyperosmotically inducible protein.	Protein of unknown function.	0.585

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.832

expected number of edges:

10

PPI enrichment p-value:

3.95e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 97

1.46

2.91

1.58e-13

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 53

1.68

3.85

9.02e-14

GO:0019843

rRNA binding

7 of 41

1.64

2.74

1.53e-08

GO:0003723

RNA binding

8 of 107

1.28

1.76

1.25e-07

GO:0000049

tRNA binding

3 of 23

1.52

0.93

0.0099

GO:0003676

Nucleic acid binding

9 of 412

0.74

0.65

0.00016

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 55

1.66

3.87

2.10e-14

GO:0015935

Small ribosomal subunit

3 of 6

2.1

2.17

4.73e-05

GO:0005622

Intracellular anatomical structure

11 of 872

0.51

0.45

4.27e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:158

Structural constituent of ribosome, and Translation regulator activity

10 of 49

1.71

4.16

8.36e-15

CL:157

Structural constituent of ribosome

11 of 61

1.66

4.04

8.77e-16

CL:159

Structural constituent of ribosome, and Translation regulator activity

9 of 42

1.74

3.98

3.05e-13

CL:161

Structural constituent of ribosome

6 of 37

1.61

2.47

1.49e-07

CL:167

rRNA-binding

5 of 24

1.72

2.41

1.29e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fro03010

Ribosome

10 of 51

1.7

4.06

1.07e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

9 of 44

1.72

3.77

1.65e-12

GOCC:0015935

Small ribosomal subunit

4 of 9

2.05

2.65

3.06e-06

GOCC:0043229

Intracellular organelle

10 of 237

1.03

1.29

1.23e-08

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 7

1.86

1.04

0.0092

GOCC:0005622

Intracellular

11 of 889

0.5

0.43

8.07e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 52

1.69

3.97

2.45e-14

KW-0699

rRNA-binding

7 of 40

1.65

2.89

4.21e-09

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