node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SIP91994.1 | SIR14649.1 | SAMN05421829_101323 | SAMN05421829_110104 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative hydrolases of HD superfamily. | 0.753 |
SIP91994.1 | guaB | SAMN05421829_101323 | SAMN05421829_10226 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.955 |
SIP91994.1 | surE | SAMN05421829_101323 | SAMN05421829_106282 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.903 |
SIP91994.1 | tadA | SAMN05421829_101323 | SAMN05421829_11438 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | tRNA-adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.421 |
SIQ30514.1 | SIR14649.1 | SAMN05421829_103313 | SAMN05421829_110104 | Deoxyadenosine/deoxycytidine kinase. | Putative hydrolases of HD superfamily. | 0.489 |
SIQ30514.1 | SIR52373.1 | SAMN05421829_103313 | SAMN05421829_11864 | Deoxyadenosine/deoxycytidine kinase. | Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. | 0.514 |
SIQ30514.1 | aroA | SAMN05421829_103313 | SAMN05421829_106253 | Deoxyadenosine/deoxycytidine kinase. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.743 |
SIQ30514.1 | surE | SAMN05421829_103313 | SAMN05421829_106282 | Deoxyadenosine/deoxycytidine kinase. | 5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.486 |
SIQ30514.1 | tadA | SAMN05421829_103313 | SAMN05421829_11438 | Deoxyadenosine/deoxycytidine kinase. | tRNA-adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.623 |
SIQ30514.1 | tmk | SAMN05421829_103313 | SAMN05421829_11444 | Deoxyadenosine/deoxycytidine kinase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.887 |
SIR14649.1 | SIP91994.1 | SAMN05421829_110104 | SAMN05421829_101323 | Putative hydrolases of HD superfamily. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.753 |
SIR14649.1 | SIQ30514.1 | SAMN05421829_110104 | SAMN05421829_103313 | Putative hydrolases of HD superfamily. | Deoxyadenosine/deoxycytidine kinase. | 0.489 |
SIR14649.1 | SIR33625.1 | SAMN05421829_110104 | SAMN05421829_11369 | Putative hydrolases of HD superfamily. | Septum formation protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.843 |
SIR14649.1 | SIR52373.1 | SAMN05421829_110104 | SAMN05421829_11864 | Putative hydrolases of HD superfamily. | Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. | 0.602 |
SIR14649.1 | aroA | SAMN05421829_110104 | SAMN05421829_106253 | Putative hydrolases of HD superfamily. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.495 |
SIR14649.1 | guaB | SAMN05421829_110104 | SAMN05421829_10226 | Putative hydrolases of HD superfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.683 |
SIR14649.1 | nudC | SAMN05421829_110104 | SAMN05421829_11519 | Putative hydrolases of HD superfamily. | NAD+ diphosphatase; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.644 |
SIR14649.1 | surE | SAMN05421829_110104 | SAMN05421829_106282 | Putative hydrolases of HD superfamily. | 5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.572 |
SIR14649.1 | tadA | SAMN05421829_110104 | SAMN05421829_11438 | Putative hydrolases of HD superfamily. | tRNA-adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.577 |
SIR14649.1 | tmk | SAMN05421829_110104 | SAMN05421829_11444 | Putative hydrolases of HD superfamily. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.498 |