STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ThiDHydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)    
Predicted Functional Partners:
ThiE
Thiamine phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.987
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.895
OOS07994.1
Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.741
MoeB
Molybdopterin biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.722
MutT
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.697
OOS05303.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.584
guaA
Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
   
 0.509
RibD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
   
  
 0.508
guaB
IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.468
thiI
tRNA 4-thiouridine(8) synthase ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.447
Your Current Organism:
Moraxella cuniculi
NCBI taxonomy Id: 34061
Other names: ATCC 14688, CCUG 2154, DSM 21768, LMG 8382, LMG:8382, M. cuniculi, NCTC 10297, Neisseria cuniculi, strain K 19
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