| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glyA | sdaA | AB406_0659 | AB406_1599 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.936 |
| glyA | thrA | AB406_0659 | AB406_1481 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Bifunctional aspartokinase/homoserine dehydrogenase 1. | 0.938 |
| glyA | trpA | AB406_0659 | AB406_1978 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain. | 0.890 |
| glyA | trpB | AB406_0659 | AB406_1977 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.903 |
| glyA | trpF | AB406_0659 | AB406_1976 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.410 |
| lgt | trpA | AB406_2312 | AB406_1978 | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Tryptophan synthase alpha chain. | 0.906 |
| lgt | trpB | AB406_2312 | AB406_1977 | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.804 |
| pabA | thrA | AB406_1972 | AB406_1481 | Aminodeoxychorismate synthase component 2. | Bifunctional aspartokinase/homoserine dehydrogenase 1. | 0.403 |
| pabA | trpA | AB406_1972 | AB406_1978 | Aminodeoxychorismate synthase component 2. | Tryptophan synthase alpha chain. | 0.973 |
| pabA | trpB | AB406_1972 | AB406_1977 | Aminodeoxychorismate synthase component 2. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.968 |
| pabA | trpC | AB406_1972 | AB406_1975 | Aminodeoxychorismate synthase component 2. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.999 |
| pabA | trpE | AB406_1972 | AB406_1971 | Aminodeoxychorismate synthase component 2. | Anthranilate synthase component 1. | 0.999 |
| pabA | trpF | AB406_1972 | AB406_1976 | Aminodeoxychorismate synthase component 2. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.986 |
| pabA | trpGD | AB406_1972 | AB406_1973 | Aminodeoxychorismate synthase component 2. | Bifunctional protein TrpGD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
| sdaA | glyA | AB406_1599 | AB406_0659 | L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.936 |
| sdaA | thrA | AB406_1599 | AB406_1481 | L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Bifunctional aspartokinase/homoserine dehydrogenase 1. | 0.894 |
| sdaA | trpA | AB406_1599 | AB406_1978 | L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase alpha chain. | 0.878 |
| sdaA | trpB | AB406_1599 | AB406_1977 | L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.859 |
| thrA | glyA | AB406_1481 | AB406_0659 | Bifunctional aspartokinase/homoserine dehydrogenase 1. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.938 |
| thrA | pabA | AB406_1481 | AB406_1972 | Bifunctional aspartokinase/homoserine dehydrogenase 1. | Aminodeoxychorismate synthase component 2. | 0.403 |
