STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDM13596.1Dihydrofolate reductase. (178 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.799
SDM13621.1
Transcriptional regulator, AraC family.
       0.773
SDM13649.1
Predicted Zn-dependent protease.
       0.773
SDM14472.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
 0.641
SDM13565.1
O-6-methylguanine DNA methyltransferase.
  
    0.540
tdk
Thymidine kinase.
   
 
 0.432
SDM08263.1
dCMP deaminase.
  
 
 0.420
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.411
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
    
 0.406
SDM55345.1
Dihydropteroate synthase.
    
 0.406
Your Current Organism:
Pedobacter antarcticus
NCBI taxonomy Id: 34086
Other names: ATCC 51969, CIP 104195 [[Pedobacter piscium]], DSM 11725 [[Pedobacter piscium]], IFO 14985 [[Pedobacter piscium]], JCM 7454 [[Pedobacter piscium]], KCTC 12489 [[Pedobacter piscium]], LMG 14024 [[Pedobacter piscium]], LMG:14024 [[Pedobacter piscium]], MTCC 675, NBRC 14985 [[Pedobacter piscium]], NCIMB 13704 [[Pedobacter piscium]], P. antarcticus, Pedobacter piscium, Sphingobacterium antarcticum, Sphingobacterium antarcticus, Sphingobacterium piscium, strain 4BY
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