STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)    
Predicted Functional Partners:
SFH03964.1
Acetolactate synthase, small subunit.
 
 
 0.998
SFF98637.1
Acetolactate synthase, small subunit.
 
 
 0.997
SFH03942.1
Acetolactate synthase, large subunit.
 
 
 0.995
SFH03987.1
Acetolactate synthase, large subunit.
 
 
 0.995
ilvD-2
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.994
ilvD
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.989
SFH24633.1
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.988
leuD-2
3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
  
 0.975
SFG82848.1
Pyruvate oxidase; Belongs to the TPP enzyme family.
 
 
 0.951
SFH14277.1
Acetolactate synthase large subunit; Belongs to the TPP enzyme family.
 
 
 0.939
Your Current Organism:
Desulfallas arcticus
NCBI taxonomy Id: 341036
Other names: D. arcticus, DSM 17038, Desulfallas arcticus (Vandieken et al. 2006) Watanabe et al. 2018, Desulfotomaculum arcticum, Desulfotomaculum arcticum Vandieken et al. 2006, JCM 12923, low G+C Gram-positive bacterium 15, strain 15
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.